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ASGR2

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein class

Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enriched (Hepatocytes)

Immune cell specificity

Group enriched (classical monocyte, myeloid DC)

Cell line specificity

Cell line enriched (Hep G2)

Interaction

The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2. (Microbial infection) Interacts with hepatitis E virus capsid protein ORF2.

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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