ATP6V1C2

Metabolic proteins, Transporters

Intracellular

Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Ionocytes, Glandular and luminal cells, Distal tubular cells, Enteroendocrine cells)

Not detected in immune cells

Group enriched (BEWO, SK-BR-3)

V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR.