Anti-BCL2L1 Recombinant Antibody Products

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Anti-BCL2L1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a leader in apoptosis and cancer research, providing the scientific community with top-tier anti-BCL2L1 (BCL-xL) recombinant antibodies. BCL-xL is a primary anti-apoptotic protein and a critical survival factor for many cancer cells and, as such, a prominent target for next-generation cancer therapeutics. Our anti-BCL-xL antibodies are world-class research tools for studying apoptosis resistance and are essential for developing and validating next-generation BH3 mimetic drugs.

BCL2L1: A Guardian Against Mitochondrial Apoptosis

The BCL2 Like 1 (BCL2L1) gene, most commonly known as BCL-xL, is a highly potent member of the BCL2 family of anti-apoptotic proteins. BCL-xL is an essential protein for maintaining normal cell survival and is a primary protector against mitochondrial apoptosis. BCL-xL is a key effector of this process as it physically binds and sequesters the pro-apoptotic “effector” proteins BAX and BAK, preventing their oligomerization and pore formation in the mitochondrial outer membrane. BCL-xL also sequesters BH3-only proteins such as BAD and BIM. Many cancers are “addicted” to the high levels of BCL-xL they express, which is why BCL-xL is such an important survival factor and drug target for cancer therapy.

Alternative Names

BCL2 Like 1; Protein Phosphatase 1, Regulatory Subunit 52; Apoptosis Regulator Bcl-X; BCL2L; BCLX; Bcl-2-Like Protein 1

Background

The protein encoded by this gene is a member of the BCL-2 protein family. BCL-2 family members, which form hetero- or homodimers, are anti- or pro-apoptotic regulators that have been implicated in a broad spectrum of cellular functions. Proteins encoded by this gene are localized to the outer mitochondrial membrane, where they have been shown to regulate opening of outer mitochondrial membrane channels (VDAC). VDAC regulates mitochondrial membrane potential and thus controls production of reactive oxygen species and release of cytochrome C by mitochondria, which are potent inducers of cell apoptosis. Alternative splicing produces multiple transcript variants encoding two different isoforms. The longer isoform is an apoptotic inhibitor, and the shorter isoform is an apoptotic activator.

Anti-BCL2L1 rAb Products

Creative Biolabs' anti-BCL2L1 recombinant antibodies are engineered for optimal specificity and performance, and are carefully validated to ensure accurate detection of the BCL-xL protein, without cross-reactivity against other BCL2 family members. Optimized for use in Western Blot, IHC, and co-immunoprecipitation applications, these rAbs are designed to provide reliable performance for studying the inner workings of the apoptosis machinery.

Table 1. Featured anti-BCL2L1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is committed to supporting the cancer research community and advancing the next generation of oncology therapeutics, which is why we have implemented a stringent quality control process for all of our products. Each batch of our anti-BCL2L1 recombinant antibody is carefully validated for purity, binding affinity, and consistent performance to ensure you receive a reliable, high-quality reagent that meets the precise demands of your apoptosis studies and targeted drug development.

Customer Reviews

Excellent

La*n
Mouse Anti-BCL2L1 Recombinant Antibody (clone 2H12)

I have used the anti-BCL-xL antibody from Creative Biolabs for research into BH3 mimetics and their effects on apoptosis. The WB clearly showed that these compounds could not decrease BCL-xL levels in our drug resistant cell lines which had very high expression levels.

12/Apr/2024

Excellent

Na*n
Mouse Anti-BCL2L1 Recombinant Antibody (clone 3D1C1)

We performed IHC on tumor samples from patients using this antibody. The staining was strong and very specific and it seemed to correlate with treatment response. A good prognostic marker.

21/Feb/2024

rAb Production

Creative Biolabs is committed to helping you make breakthroughs in cancer research by using the latest, most advanced production platforms. Our anti-BCL2L1 recombinant antibodies are expressed in highly optimized systems to ensure they recognize the native protein with the highest fidelity, which gives you a product that has high biological relevance and activity for your research.

Featured Anti-BCL2L1 Recombinant Antibody Production Platforms
Fig.4 Milligram-scale anti-BCL2L1 recombinant antibody production.

Fig.5 Gram-scale anti-BCL2L1 recombinant antibody production.

rAb Modalities

Creative Biolabs is passionate about providing innovative, flexible products to meet the demands of cutting-edge cancer research. Our anti-BCL2L1 recombinant antibodies are available in a variety of customizable modalities to help researchers around the world study this critical survival protein.

Fig.6 Full-length anti-BCL2L1 recombinant antibody production and modalities.

Explore apoptosis resistance mechanisms with Creative Biolabs' anti-BCL2L1 recombinant antibodies. Built on a foundation of extensive validation and unmatched consistency, our portfolio of antibodies is designed to give you the ideal tools for studying this important oncogenic protein. Choose Creative for quality that moves science forward. Get in touch with our team today.

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