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BDP1
The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (TIME)
Interaction
Component of TFIIIB complex. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha and TFIIIB-beta activities are required for transcription of genes with TFIIIC-bound internal promoters and PSE transcription factor-bound external promoters, respectively. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; YY1 facilitates the formation of TFIIIB-alpha activity complex. The TFIIIB-beta activity complex is composed of TBP, BDP1, and BRF1. Interacts with BRF1; this interaction diminishes during mitosis resulting in the release of BDP1 from chromosomal templates. Component of TFIIIC complex. The TFIIIC complex has two activities, C1 and C2. The TFIIIC2 activity complex is only required for transcription of the 'classical' pol III genes whereas the TFIIIC1 activity complex is required for transcription of all pol III genes. The TFIIIC1 activity complex is composed at least of BDP1. Interacts with ZBTB43.
Molecular function
Activator
More Types Infomation
- Mouse Anti-BDP1 Recombinant Antibody (clone 3084E2b) (MOB-0818CT)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: DB, WB
- transferrin-ABR immunotoxin (AGTO-G074A)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
- Human Anti-BDP1 Antibody, mRNA (AGTO-G074A-mRNA)
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- Species Reactivity: Human
- transferrin-PAP immunotoxin (AGTO-G074P)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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For Research Use Only. Not For Clinical Use.