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BIRC7
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- A*02:01/Human BIR7 (RLASFYDWPL) MHC Pentamer (MHC-YF335)
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- Class: Class I
- Antigen: BIR7
- Antigen Species: Human
- Peptide: RLASFYDWPL
- Conjugate: Unlabeled, Biotin, R-PE, APC
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- A*02:01/Human BIR7 (VLEPPGARDV) MHC Pentamer (MHC-YF334)
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- Class: Class I
- Antigen: BIR7
- Antigen Species: Human
- Peptide: VLEPPGARDV
- Conjugate: Unlabeled, Biotin, R-PE, APC
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- PE-A*02:01/Human LIVIN (QLCPICRAPV) MHC Tetramer (MHC-LC060)
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- Class: Class I
- Antigen: LIVIN
- Antigen Species: Human
- Peptide: QLCPICRAPV
- Conjugate: PE
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- Mouse Anti-BIRC7 Recombinant Antibody (clone 99D680) (MOB-1253MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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- Recombinant Anti-Human BIRC7 Antibody scFv Fragment (MOB-2973z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: IF, FC, Biosensors, FuncS
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- Recombinant Anti-Human BIRC7 Antibody Fab Fragment (MOB-2973z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: FC, IP, FuncS
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- Anti-BIRC7 Immunohistochemistry Kit (VS-0525-XY777)
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- Species Reactivity: Human
- Target: BIRC7
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Hofbauer cells, Muller glia cells, Melanocytes, Extravillous trophoblasts, Cytotrophoblasts)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (SK-MEL-30)
Interaction
Binds to CASP9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to CASP9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with CASP3 and CASP7 via its BIR domain.
Molecular function
Protease inhibitor, Thiol protease inhibitor, Transferase
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