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BUB1
Loading...Anti-BUB1 Products
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- Species Reactivity: Mouse, Human. Predicted to work with: Rat, Xenopus laevis, Kangaroo
- Type: Mouse IgG1
- Application: IF, WB, IP
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC
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- Anti-BUB1 Immunohistochemistry Kit (VS-0525-XY860)
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- Species Reactivity: Human
- Target: BUB1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes, Granulosa cells, Plasma cells, Erythroid cells, Spermatogonia)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HEL)
Interaction
Interacts with BUB3 and KNL1. Interacts (when phosphorylated) with PLK1. The BUB1-BUB3 complex interacts with MAD1L1. (Microbial infection) Interacts with SV40 Large T antigen; this interaction induces activation of a DNA damage response and promotes p53/TP53 stabilization and phosphorylation. (Microbial infection) Interacts with herpes virus 8 protein LANA1.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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