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BCL11B
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (T-cells, Inhibitory neurons, Basal squamous epithelial cells, Suprabasal keratinocytes, Basal keratinocytes, Excitatory neurons, NK-cells)
Immune cell specificity
Group enriched (naive CD4 T-cell, naive CD8 T-cell, memory CD4 T-cell, memory CD8 T-cell, T-reg, gdT-cell, MAIT T-cell)
Cell line specificity
Group enriched (JURKAT, MOLT-4)
Interaction
Interacts with TFCOUP1, SIRT1, ARP1 and EAR2 (By similarity). Interacts with EP300; the interaction is detected in activated T-lymphocytes, but not under resting conditions (PubMed:27959755).
Molecular function
Repressor
More Types Infomation
- Rabbit Anti-BCL11B Recombinant Antibody (clone 25B6) (FAMAB-1018CQ)
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- Species Reactivity: Guinea Pig, Rat, Zebrafish, Human, Cynomolgus monkey, Mouse
- Type: Rabbit IgG
- Application: IB, IHC
- Rabbit Anti-BCL11B Recombinant Antibody (clone JF09-90) (MRO-0399-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.