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BLK
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (B-cells)
Immune cell specificity
Group enriched (memory B-cell, naive B-cell)
Cell line specificity
Cell line enhanced (Daudi, REH, RPMI-8226, U-698, U-87 MG)
Interaction
Interacts with CBL (via SH2 domain). Interacts with CD79A and CD79B (via SH2 domain) (By similarity).
Molecular function
Kinase, Transferase, Tyrosine-protein kinase
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
- Mouse Anti-BLK Recombinant Antibody (clone 9D10B7) (MOB-0469MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
- Mouse Anti-BLK Recombinant Antibody (clone 29F6) (MOB-1366z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC, WB
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: IHC, ELISA
- Mouse Anti-BLK Recombinant Antibody (clone 1E6) (VS3-XY125)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, ICC, FC
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- Species Reactivity: Human
- Type: Mouse IgG1
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For Research Use Only. Not For Clinical Use.