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BMP6
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Microglial cells, Adipocytes, Inhibitory neurons, Hepatic stellate cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (EFO-21, HUVEC TERT2, Karpas-707, SiHa, TIME, U-266/84)
Interaction
Interacts with SOSTDC1 (By similarity). Interacts (when glycosylated) with type I receptor ACVR1 (PubMed:18070108). Interacts with type II receptor ACVR2B (PubMed:18070108). Interacts with Hemojuvelin/HJV (By similarity).
Molecular function
Cytokine, Developmental protein, Growth factor
More Types Infomation
- Rat Anti-BMP6 Recombinant Antibody (clone CBL643) (NEUT-063CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2b
- Application: Neut
- Mouse Anti-BMP6 Recombinant Antibody (clone CBL492) (NEUT-062CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, Neut, ELISA
- Mouse Anti-BMP6 Recombinant Antibody (clone CBL491) (NEUT-061CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ELISA(Cap), Neut
- Mouse Anti-BMP6 Recombinant Antibody (clone CBL283) (NEUT-060CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, Neut, WB
- Mouse Anti-BMP6 Recombinant Antibody (clone CBL109) (NEUT-059CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2
- Application: Neut, WB
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, ICC, IHC-P, FC
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB, FuncS
- Mouse Anti-BMP6 Recombinant Antibody (clone 10H10) (NEUT-058CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2
- Application: Neut, WB
- Human Anti-BMP6 Recombinant Antibody (HPAB-0183-CN) (HPAB-0183-CN)
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- Derivation: Human antibody phage display library
- Species Reactivity: Human, Mouse
- Type: Human IgG1
- Application: ELISA
- Human Anti-BMP6 Recombinant Antibody (HPAB-0182-CN) (HPAB-0182-CN)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Human Anti-BMP6 Recombinant Antibody (HPAB-0181-CN) (HPAB-0181-CN)
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- Species Reactivity: Human, Rat, Cynomolgus monkey
- Type: Human IgG
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Anti-Human BMP6 Recombinant Antibody (TAB-070CL)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Antibody
- Human Anti-BMP6 Recombinant Antibody; Fab Fragment (HPAB-0183-CN-F(E)) (HPAB-0183-CN-F(E))
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- Derivation: Human antibody phage display library
- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: ELISA
- Human Anti-BMP6 Recombinant Antibody; Fab Fragment (HPAB-0182-CN-F(E)) (HPAB-0182-CN-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
- Human Anti-BMP6 Recombinant Antibody; Fab Fragment (HPAB-0181-CN-F(E)) (HPAB-0181-CN-F(E))
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- Species Reactivity: Human, Rat, Cynomolgus monkey
- Type: Human Fab
- Application: ELISA
- Human Anti-BMP6 Recombinant Antibody; scFv Fragment (HPAB-0183-CN-S(P)) (HPAB-0183-CN-S(P))
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- Derivation: Human antibody phage display library
- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: ELISA
- Human Anti-BMP6 Recombinant Antibody; scFv Fragment (HPAB-0182-CN-S(P)) (HPAB-0182-CN-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
- Human Anti-BMP6 Recombinant Antibody; scFv Fragment (HPAB-0181-CN-S(P)) (HPAB-0181-CN-S(P))
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- Species Reactivity: Human, Rat, Cynomolgus monkey
- Type: Human scFv
- Application: ELISA
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For Research Use Only. Not For Clinical Use.