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CALML5
This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.
Protein class
Plasma proteins, RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Suprabasal keratinocytes, Breast glandular cells, Breast myoepithelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (A-431)
Interaction
Associates with transglutaminase 3.
More Types Infomation
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, ICC, IF
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For Research Use Only. Not For Clinical Use.