CCNE2

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For Research Use Only. Not For Clinical Use.


Background

CCNE2 (Cyclin E2) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Cyclins and Cell Cycle Regulation. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CCNE1.
Protein class

Cancer-related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Spermatocytes, Oligodendrocytes, Erythroid cells, Spermatogonia)

Immune cell specificity

Immune cell enhanced (T-reg)

Cell line specificity

Cell line enhanced (Karpas-707)

Interaction

Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

Molecular function

Cyclin

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