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Anti-CCR8 Recombinant Antibody Products

Anti-CCR8 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs offers a comprehensive portfolio of anti-CCR8 recombinant antibodies, designed to meet the diverse needs of researchers investigating immune function and related diseases. Our precision-engineered products are designed to deliver superior specificity, sensitivity, and reproducibility, ensuring the highest standards of accuracy and reliability in your research endeavors. Whether you're exploring basic immunology or developing novel therapeutic approaches, Creative Biolabs is your trusted partner in CCR8 antibody research.

CCR8: A Crucial and Efficient Target for Cancer Treatment

CCR8, a key receptor involved in Treg recruitment to tumors, plays a crucial role in creating an immunosuppressive environment that shields tumors from immune attack. By inhibiting CCR8 with antibodies, researchers aim to disrupt Treg accumulation, potentially enhancing anti-tumor immune responses and hindering tumor growth. Recent studies have demonstrated the efficacy of anti-CCR8 antibodies in reducing Treg infiltration and their immunosuppressive effects within tumors, suggesting that targeting CCR8 holds significant potential for developing innovative cancer therapies.

Alternative Names

CCR-8; Chemokine (C-C motif) receptor 8; C-C chemokine receptor 8; C-C motif chemokine receptor 8; CC-CKR-8; CDw198; CMKBR8; CKRL1; CMKBRL2; TER1; CY6; GPRCY6.

Background

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.

Protein class

CD markers, G-protein coupled receptors

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (T-cells)

Immune cell specificity

Immune cell enriched (T-reg)

Cell line specificity

Cell line enriched (HDLM-2)

Molecular function

G-protein coupled receptor, Receptor, Transducer

More Types Infomation

Anti-CCR8 rAb Products

Creative Biolabs offers a versatile selection of recombinant CCR8 antibodies, engineered in various formats to meet diverse research needs. Our antibodies empower researchers to conduct precise and efficient experiments, advancing your projects with confidence.

Table 1. Featured anti-CCR8 recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
MOB-3049z-F(E) Recombinant Anti-Human CCR8 Antibody Fab Fragment Human Mouse Fab Radioimmunoassay, Immunofluorescence, Functional Study
NEUT-274CQ Rat Anti-CCR8 Recombinant Antibody (clone CBL712) Human Rat IgG2b Neut
ZG-0139U Human Anti-CCR8 Recombinant Antibody (clone 2C6) Human Human hgG1 FC
MOB-3049z Mouse Anti-CCR8 Recombinant Antibody Human Mouse IgG1, κ FC
MOB-019CQ Rabbit Anti-Human CCR8 Antibody Human Rabbit IgG ELISA, WB, IHC

Creative Quality Control

Creative Biolabs is committed to delivering premium anti-CCR8 recombinant antibodies, engineered for groundbreaking immunological research. Our state-of-the-art laboratories adhere to rigorous quality control protocols to ensure each antibody exhibits exceptional specificity and efficacy. By continuously refining our production techniques, our team of experts ensures that our offerings remain at the forefront of antibody research.

Fig.1 FC analysis. (Creative Biolabs Original)Fig.1 FC analysis of anti-CA9 antibody
(Cat# ZG-0139U, Creative Biolabs).

Customer Reviews

Excellent
Da***n
Rat Anti-CCR8 Recombinant Antibody (clone CBL712) (NEUT-274CQ)
I was incredibly impressed with the quality and performance of Creative Biolabs' anti-CCR8 recombinant antibody. The antibody's exceptional specificity and sensitivity enabled me to attain outstanding results in my research. The technical support provided by their team was exceptional, and they were always willing to assist with any questions or concerns
22/May/2021
Excellent
Cl***e
Mouse Anti-CCR8 Recombinant Antibody (MOB-3049z) (MOB-3049z)
I've been using Creative Biolabs' anti-CCR8 antibodies for several experiments now, and I've always been satisfied with their products. The antibodies are reliable, and consistent, and have helped me to make significant progress in my research. I wholeheartedly recommend Creative Biolabs' anti-CCR8 antibodies to all researchers in the field of immunology.
9/Oct/2022
Excellent
Em***y
Rabbit Anti-CCR8 Recombinant Antibody (clone R07-8E8) (VS3-XY3291)
I recently purchased an anti-CCR8 antibody from Creative Biolabs, and I couldn't be happier with my decision. The antibody was delivered quickly and was of excellent quality. I was able to obtain clear and reproducible results in my experiments, and the technical support provided by Creative Biolabs was invaluable.
19/Nov/2023

rAb Production

Our proprietary anti-CCR8 recombinant antibody platform leverages genetically engineered cells to produce high-quality, CCR8-specific antibodies. This cutting-edge system enables scalable and efficient production, guaranteeing a reliable supply for diverse applications.

Featured Anti-CCR8 Recombinant Antibody Production PlatformsFig.2 Milligram-scale. (Creative Biolabs Original)
Fig.2 Milligram-scale anti-CCR8 recombinant antibody production.

Fig.3 Gram-scale. (Creative Biolabs Original)Fig.3 Gram-scale anti-CCR8 recombinant antibody production.

rAb Modalities

Creative Biolabs provides a comprehensive range of high-quality anti-CCR8 recombinant antibodies, available in diverse formats to accommodate a variety of research applications.

Fig.4 CCR8 antibody production and modalities. (Creative Biolabs Original)Fig.4 Full-length anti-CCR8 recombinant antibody production and modalities.

CCR8-Targeted Drug Information

Table 2. Public drug targeting CCR8.

Highest Phase Mechanism of Action Product Category Condition Organization
Phase I/II Anti-CCR8 (C-C Chemokine Receptor Type 8) Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer, solid tumor LaNova Medicines (Originator)
Preclinical Anti-CCR8 (C-C Chemokine Receptor Type 8)
Anti-CTLA4 (Cytotoxic T-Lymphocyte Protein 4; CD152)
Immune Checkpoint Inhibitors
Bispecific Antibody Fusions
Cancer Immunotherapy
Fusion Proteins
Monoclonal Antibodies
Polypeptides, from 41 AA
Single-Chain V-Domain Antibody Fragment (scFv)
Cancer, colorectal Mabwell (Shanghai) Bioscience (Originator)
Preclinical Anti-CCR8 (C-C Chemokine Receptor Type 8)
Anti-CTLA4 (Cytotoxic T-Lymphocyte Protein 4; CD152)
Immune Checkpoint Inhibitors
Bispecific Antibodies
Cancer Immunotherapy
Cancer, colorectal Biotheus (Originator)
Preclinical Anti-CCR8 (C-C Chemokine Receptor Type 8)
Anti-CTLA4 (Cytotoxic T-Lymphocyte Protein 4; CD152)
Immune Checkpoint Inhibitors
Antibody-Derived Binding Proteins
Bispecific Antibody Fusions
Cancer Immunotherapy
Fc Fusion Proteins
Polypeptides, from 41 AA
Single-Domain Antibodies
Cancer Genor Biopharma (Originator)
Biological Testing Anti-CCR8 (C-C Chemokine Receptor Type 8)
Anti-TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily Member 1B; TNFR2)
Signal Transduction Modulators
Bispecific Antibody Fusions
Cancer Immunotherapy
Human Monoclonal Antibodies
Polypeptides, from 41 AA
Single-Domain Antibodies
Cancer Excel Harvest (China) Biopharmaceutical (Originator)
Biological Testing C-C Chemokine Receptor Type 8 (CCR8) Ligands
Drugs Targeting B-Lymphocyte Antigen CD19
Signal Transduction Modulators
Cancer Immunotherapy
Chimeric Antigen Receptor-Modified T Cells (CAR T Cells) (Second-Generation CAR)
Autoimmune disease
Cancer
Infections
Transplant rejection
Nanjing Bioheng Biotechnology (Originator)
Biological Testing C-C Chemokine Receptor Type 8 (CCR8) Ligands
Drugs Targeting T-Cell Surface Glycoprotein CD3
Signal Transduction Modulators
T-Cell Engagers
Bispecific Antibody Fusions
Cancer Immunotherapy
Fusion Proteins
Polypeptides, from 41 AA
Single-Chain V-Domain Antibody Fragment (scFv)
Cancer, solid tumor Amgen (Originator)
Biological Testing Drugs Targeting Mesothelin Cancer Immunotherapy
Chimeric Antigen Receptor-Modified T Cells (CAR T Cells) (Second-Generation CAR)
Cancer LMU Klinikum (Originator)

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Need a top-notch anti-CCR8 antibody? Creative Biolabs has you covered. Contact us to chat about your research and find the perfect fit.

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