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    CD33 & DENV

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    Anti-CD33 & DENV Products

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    For Research Use Only. Not For Clinical Use.


    Background

    Dengue virus (DENV), a member of the family Flaviviridae, is a mosquito-borne pathogen with four distinct serotypes including DENV-1 to DENV-4. Currently, it is estimated that DENV infects about 390 million cases globally each year, resulting in 96 million cases clinically apparent from mild fever to dengue hemorrhagic fever (DHF) or the life-threatening dengue shock syndrome (DSS).
    CD33 & DENV
    Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
    CD33 & DENV
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