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CD33

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CD33 is a transmembrane receptor expressed on myeloid lineage cells. It is usually thought to be myeloid-specific, but it can also be found on some lymphocytes. It binds sialic acid and is therefore a member of the SIGLEC lectin family. The extracellular portion of this receptor contains two immunoglobulin domains (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily. The intracellular portion of CD33 contains an immunoreceptor tyrosine-based inhibition motif (ITIM) involved in the inhibition of cellular activity. Diseases associated with CD33 include gallbladder lymphoma and extra-cutaneous lymphoma. Its related pathways include hematopoietic stem cell differentiation pathways and lineage-specific markers as well as the innate immune system. Vadastuximab is an antibody against CD33. The reagent was developed by the Seattle Genetics Institute and is currently in clinical trials for the treatment of acute myeloid leukemia (AML). To date, acute myelogenous leukemia remains a major challenge in the treatment of hematologic oncology.

Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IF, IP, Neut, FuncS, ELISA, FC, ICC
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Targets:
CD33 & CD3
Type:
BiTE
Application:
FuncS, Promising therapeutic agent
Targets:
CD33 & CD3
Type:
F(ab')2
Application:
FuncS, Promising therapeutic agent
Targets:
CD33 & DENV
Type:
CrossMab
Application:
FuncS, Promising therapeutic agent
Targets:
FcγRI & CD33
Type:
CrossMab
Application:
FuncS, Promising therapeutic agent
Targets:
CD33 & FcγRIII
Type:
TandAb
Application:
FuncS, Promising therapeutic agent
Type:
Human antibody
Application:
FC
Application:
ELISA, FC
Species Reactivity:
Cynomologous
Application:
ELISA, FC
Species Reactivity:
Cynomologous
Application:
ELISA, FC
Application:
ELISA, FC
Species Reactivity:
Cynomologous
Application:
ELISA, FC
Species Reactivity:
Cynomologous
Application:
ELISA, FC
Application:
ELISA, FC
Species Reactivity:
Cynomologous
Application:
ELISA, FC
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