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CD70

Engineered Antibody Glyco-Abs
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
CD70
  • Anti-CD70(h1F6)-mc-vc-PBD ADC (ADC-176LCT)
    • Target: CD70
    • Linker: mc-VC (maleimidocaproyl-valine-citrulline)
    • Drug: pyrrolobenzodiazepine (PBD) dimers
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  • Anti-CD27L-DM1 ADC (ADC-127LZY)
    • Target: CD27L
    • Linker: Noncleavable thioether linker
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD70 (clone h1F6)-MCC-DM1 ADC (ADC-052LZY)
    • Target: CD70
    • Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD27L-MCC-DM1 ADC (ADC-038LZY)
    • Target: CD27L
    • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD70 (c1F6)-vc-AFP ADC (ADC-072LCT)
    • Target: CD70
    • Linker: VC (valine-citrulline)
    • Drug: AFP (auristatin phenylalanine phenylenediamine)
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  • Anti-CD70 (h1F6)-vc-AFP ADC (ADC-071LCT)
    • Target: CD70
    • Linker: VC (valine-citrulline)
    • Drug: AFP (auristatin phenylalanine phenylenediamine)
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  • Anti-CD70 (clone 2F2)-vc-AFP ADC (ADC-115CL)
    • Target: CD70
    • Linker: VC (valine-citrulline)
    • Drug: AFP (dimethylvaline-valine-dolaisoleuine-dolaproine-phenylalanine-p-phenylenediamine)
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  • Anti-CD70 (clone 1F6)-vc-AFP ADC (ADC-112CL)
    • Target: CD70
    • Linker: VC (valine-citrulline)
    • Drug: AFP (dimethylvaline-valine-dolaisoleuine-dolaproine-phenylalanine-p-phenylenediamine)
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