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CD8B

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For Research Use Only. Not For Clinical Use.


Predicted to enable MHC class I protein binding activity and coreceptor activity. Predicted to be involved in T cell activation and T cell receptor signaling pathway. Located in external side of plasma membrane. Part of receptor complex. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to several human genes including CD8B (CD8 subunit beta).
Protein class

CD markers

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (T-cells, dendritic cells)

Immune cell specificity

Group enriched (naive CD8 T-cell, memory CD8 T-cell)

Cell line specificity

Cell line enriched (RPMI-8226)

Interaction

Forms disulfide-linked heterodimers with CD8A at the cell surface. Interacts with CD3D; this interaction couples TCR-CD3 with CD8. Interacts with LCK.

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