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CDC25C

This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described.
Protein class

Cancer-related genes, Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Spermatocytes, Late spermatids, Early spermatids, Spermatogonia)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Low cell line specificity

Interaction

Interacts with MAPK14 and 14-3-3 proteins. When phosphorylated on Ser-129 and/or Thr-130, interacts with PLK1. (Microbial infection) Interacts with HIV-1 Vpr; this interaction inactivates CDC25C phosphatase activity.

Molecular function

Hydrolase, Protein phosphatase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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