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CHIT1

Anti-CHIT1 Products
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- Species Reactivity: Human
- Application: ELISA, WB
- Mouse Anti-CHIT1 Recombinant Antibody (clone CBL270) (NEUT-460CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, IP, Neut
- Mouse Anti-CHIT1 Recombinant Antibody (clone CBL772) (NEUT-461CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IP, Neut
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- Species Reactivity: E. coli, Human
- Type: Mouse IgG
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
Protein class
Candidate cardiovascular disease genes, Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enriched (Hofbauer cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Monomer.
Molecular function
Glycosidase, Hydrolase
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