Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
At Creative Biolabs, we are dedicated to advancing cancer research through the provision of exceptional tools and resources. Our comprehensive collection of anti-CHRM1 antibodies is designed to meet the rigorous demands of modern scientific investigations. With a team of experienced scientists and technicians, we offer unparalleled technical support and a wealth of validated data to facilitate your research endeavors.
CHRM1 (Cholinergic Receptor, Muscarinic 1) is a G-protein coupled receptor with a pivotal role in regulating diverse physiological functions. CHRM1's involvement in cardiovascular health, gastrointestinal function, neurological processes, and urinary bladder control has led to its exploration as a potential treatment for conditions such as bradycardia, irritable bowel syndrome, Alzheimer's disease, and overactive bladder. Its broad expression in the body makes it a promising target for therapeutic intervention in a variety of illnesses.
Muscarinic acetylcholine receptor M1; cholinergic receptor muscarinic 1; cholinergic receptor, muscarinic 1; HM1; M1; M1R.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
FDA approved drug targets, G-protein coupled receptors
Membrane
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Prostatic glandular cells, Breast myoepithelial cells, Melanocytes, Intestinal goblet cells, Oligodendrocyte precursor cells, Astrocytes)
Not detected in immune cells
Group enriched (MCF7, OE19)
Interacts with GPRASP2 (PubMed:15086532). Interacts with TMEM147 (PubMed:21056967).
G-protein coupled receptor, Receptor, Transducer
Creative Biolabs offers a comprehensive suite of high-quality anti-CHRM1 recombinant antibodies designed to facilitate cutting-edge cancer research. Our antibodies are meticulously engineered for optimal specificity and affinity, enabling researchers to investigate the intricate role of CHRM1 in tumorigenesis and progression. With a diverse range of formats and applications, our products are invaluable tools for advancing the understanding of cancer biology and accelerating the development of innovative therapeutic strategies.
Table 1. Featured anti-CHRM1 recombinant antibody products at Creative Biolabs.
Cat. No. | Product Name | Target Species | Host Species | Applications |
MOB-2014z | Mouse Anti-CHRM1 Recombinant Antibody (clone 36C10) | Human | Mouse IgG2a, κ | WB, ELISA, IF, IP |
Creative Biolabs is a leading provider of high-quality anti-CHRM1 antibodies, meticulously engineered for optimal specificity and affinity. Our whole product line is extensively tested to ensure great performance and dependability across a wide range of applications. By adhering to stringent quality control standards, we empower researchers to achieve consistent and accurate results, driving advancements in their understanding of cancer biology and accelerating the development of innovative therapeutic strategies.
Creative Biolabs leverages cutting-edge recombinant antibody technology to generate potent and flexible anti-CHRM1 antibodies, customized to fulfill a wide range of research needs. Our innovative technique enables us to provide high-quality anti-CHRM1 antibodies with efficacy and accuracy that help greatly with scientific research and discoveries.
Featured Anti-CHRM1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CHRM1 recombinant antibody production.
Fig.2 Gram-scale anti-CHRM1 recombinant antibody production.
Creative Biolabs provides a comprehensive selection of excellent anti-CHRM1 recombinant antibodies in numerous forms to help customers with their significant projects.
Fig.3 CHRM1 antibody production and modalities. (Creative Biolabs Original)
Table 2. Public drug targeting CHRM1.
Highest Phase | Mechanism of Action | Product Category | Condition | Organization |
Pre-Registered |
Muscarinic M1 Receptor Agonists Muscarinic M4 Receptor Agonists Muscarinic Receptor Antagonists Signal Transduction Modulators |
Fixed-Dose Combinations |
Psychosis Schizophrenia |
Karuna Pharmaceuticals (Karuna Therapeutics) Karuna Therapeutics (Originator) Zai Lab Zai Lab |
Phase II |
Anticholinergics Muscarinic M1 Receptor Agonists Muscarinic Receptor Agonists Muscarinic Receptor Antagonists Signal Transduction Modulators |
Fixed-Dose Combinations | Presbyopia |
LENZ Therapeutics (Originator) Presbyopia Therapies (LENZ Therapeutics) |
Phase II |
Acetylcholinesterase (AChE) Inhibitors Drugs Targeting NMDA Receptors Drugs Targeting Sodium Channels Lipid Peroxidation Inhibitors Muscarinic M1 Receptor Agonists sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) Agonists Signal Transduction Modulators |
Fixed-Dose Combinations | Dementia, Alzheimer's type | Anavex Life Sciences (Originator) |
Phase I |
Muscarinic M1 Receptor Agonists Muscarinic M4 Receptor Agonists Muscarinic Receptor Antagonists Signal Transduction Modulators |
Fixed-Dose Combinations |
Dyskinesia Psychosis Schizophrenia |
MapLight Therapeutics (Originator) |
Preclinical |
Angiotensin Converting Enzyme (ACE; DCP) Inhibitors Muscarinic M1 Receptor Agonists Signal Transduction Modulators |
Natural Products Oligopeptides, less than 10 AA Type-C Natriuretic Peptides |
Hypertension |
Instituto Butantan Universidade de Sao Paulo (USP) |
(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)
Table 3. Clinical drug targeting CHRM1.
Highest Phase | Mechanism of Action | Product Category | Condition | Organization |
Biological Testing |
Muscarinic M1 Receptor Antagonists Signal Transduction Modulators |
Polypeptides, from 10 AA to 40 AA |
Cataract Chronic obstructive pulmonary disease (COPD) Dementia, Alzheimer type Ulcer, peptic |
Shanghai Jiao Tong University (SJTU) (Originator) |
Biological Testing |
Muscarinic M1 Receptor Ligands Muscarinic M2 Receptor Ligands Muscarinic M3 Receptor Antagonists Muscarinic M4 Receptor Ligands Muscarinic M5 Receptor Ligands Signal Transduction Modulators |
Chronic obstructive pulmonary disease (COPD) | Pfizer (Originator) | |
Biological Testing |
Muscarinic M1 Receptor Agonists Signal Transduction Modulators |
Merck & Co (Originator) | ||
Biological Testing |
Muscarinic M1 Receptor Agonists Signal Transduction Modulators |
Cognitive disorders | AstraZeneca (Originator) |
(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)
Creative Biolabs is a prominent supplier of cutting-edge antibody solutions, fusing a strong theoretical foundation with a wealth of real-world experience. Our economical, high-quality anti-CHRM1 antibodies are designed to meet the exacting requirements of the most recent studies. Don't hesitate to get in touch with us to discover more about our extensive product line and how our antibodies could assist you in furthering your research.