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CLDN4
Loading...Anti-CLDN4 Products
- Anti-Human CLDN4 Recombinant Antibody (KM3900) (TAB-501LC)
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- Application: WB, IP, FC
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- Anti-Human CLDN4 Recombinant Antibody (KM3907) (TAB-504LC)
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- Application: Cyt, FC, WB
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- Anti-Human CLDN4 Recombinant Antibody (cKM3907) (TAB-505LC)
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: Cyt, FC, WB
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- Anti-Human CLDN4 Recombinant Antibody scFv Fragment (cKM3907) (TAB-505LC-S(P))
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
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- Anti-Human CLDN4 Recombinant Antibody Fab Fragment (cKM3900) (TAB-502LC-F(E))
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
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- Anti-Human CLDN4 Recombinant Antibody scFv Fragment (cKM3900) (TAB-502LC-S(P))
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
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- Anti-Human CLDN4 Recombinant Antibody (cKM3900) (TAB-502LC)
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: Cyt, FC, WB
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- Anti-Human CLDN4 Recombinant Antibody (TAB-169CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
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- Anti-Human CLDN4 Recombinant Antibody Fab Fragment (cKM3907) (TAB-505LC-F(E))
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
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- Human Anti-CLDN4 Antibody, mRNA (TAB-169CL-mRNA)
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- Species Reactivity: Human
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- Anti-Human CLDN4 Recombinant Antibody scFv Fragment (KM3907) (TAB-504LC-S(P))
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- Application: WB, IP
Compare
- Anti-Human CLDN4 Recombinant Antibody Fab Fragment (TAB-506LC-F(E)) (TAB-506LC-F(E))
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- Species Reactivity: Mouse
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- Anti-Human CLDN4 Recombinant Antibody Fab Fragment (KM3907) (TAB-504LC-F(E))
-
- Application: WB, IP
Compare
- Anti-Human CLDN4 Recombinant Antibody scFv Fragment (TAB-506LC-S(P)) (TAB-506LC-S(P))
-
- Species Reactivity: Mouse
Compare
- Anti-Human CLDN4 Recombinant Antibody Fab Fragment (KM3900) (TAB-501LC-F(E))
-
- Application: WB, IP
Compare
- Anti-Human CLDN4 Recombinant Antibody scFv Fragment (KM3900) (TAB-501LC-S(P))
-
- Application: WB, IP
Compare
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- Species Reactivity: Mouse
- Target: CLDN4
- Host Animal: Rat
- Application: ELISA, FC, Cell-uptake
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- Anti-CLDN4 Immunohistochemistry Kit (VS-0525-XY1487)
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- Species Reactivity: Human
- Target: CLDN4
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a high-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein augments alveolar epithelial barrier function and is induced in acute lung injury. It is highly expressed in pancreatic and ovarian cancers.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Urothelial cells, Basal prostatic cells, Glandular and luminal cells, Prostatic glandular cells, Paneth cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (A-431, BEWO, CAPAN-2, MCF7, OE19, PC-3, RT4, SK-BR-3)
Interaction
Directly interacts with TJP1/ZO-1 (PubMed:16236711). Interacts with TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with EPHA2; phosphorylates CLDN4 and may regulate tight junctions (PubMed:16236711). Interacts with CLDN1 (PubMed:20375010). Interacts with CLDN8 (By similarity). (Microbial infection) Interacts (via both extracellular domains) with Clostridium perfringens enterotoxin CPE; the interaction may disrupt claudin assembly in tight junctions.
Molecular function
Chloride channel, Ion channel
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