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CLDN4

The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Urothelial cells, Basal prostatic cells, Glandular and luminal cells, Prostatic glandular cells, Paneth cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (A-431, BEWO, CAPAN-2, MCF7, OE19, PC-3, RT4, SK-BR-3)

Interaction

Directly interacts with TJP1/ZO-1 (PubMed:16236711). Interacts with TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with EPHA2; phosphorylates CLDN4 and may regulate tight junctions (PubMed:16236711). Interacts with CLDN1 (PubMed:20375010). Interacts with CLDN8 (By similarity). (Microbial infection) Interacts (via both extracellular domains) with Clostridium perfringens enterotoxin CPE; the interaction may disrupt claudin assembly in tight junctions.

Molecular function

Chloride channel, Ion channel

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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