CLEC12A & CD3

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.

Enables pattern recognition receptor activity and transmembrane signaling receptor activity. Involved in several processes, including negative regulation of dendritic cell differentiation; negative regulation of leukocyte activation; and positive regulation of type I interferon production. Is active in plasma membrane. Is expressed in embryo mesenchyme; liver left lobe; liver right lobe; olfactory epithelium; and thymus primordium. Orthologous to human CLEC12A (C-type lectin domain family 12 member A).