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CLINT1

This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Protein class

Plasma proteins, Transporters

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Immune cell enriched (basophil)

Cell line specificity

Low cell line specificity

Interaction

Binds clathrin heavy chain and AP-2 (PubMed:12213833, PubMed:12429846, PubMed:12538641). Interacts with VTI1B (PubMed:18033301). Interacts with GGA2 (via GAE domain) (PubMed:12213833, PubMed:14665628). Interacts with AP1G1 (via GAE domain) (PubMed:12213833, PubMed:12429846, PubMed:12538641, PubMed:14665628). Interacts with AP1G2 (via GAE domain) (PubMed:14665628).

More Types Infomation

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