Plasma proteins
Intracellular, Membrane (different isoforms)
Cell type enhanced (Muller glia cells, Astrocytes, Paneth cells, Fibroblasts)
Not detected in immune cells
Group enriched (AF22, SH-SY5Y)
Forms a heterotrimer with LIFR and IL6ST. Interacts with heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303). Either alone or in complex with the heterodimer CLCF1-CRLF1 interacts with SORL1; this interaction may promote internalization and lysosomal degradation (PubMed:26858303). Component of a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR which interacts with the neuroprotective peptide humanin (PubMed:19386761).
Receptor
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For Research Use Only. Not For Clinical Use.