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CNTFR

Protein class

Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Muller glia cells, Astrocytes, Paneth cells, Fibroblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (AF22, SH-SY5Y)

Interaction

Forms a heterotrimer with LIFR and IL6ST. Interacts with heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303). Either alone or in complex with the heterodimer CLCF1-CRLF1 interacts with SORL1; this interaction may promote internalization and lysosomal degradation (PubMed:26858303). Component of a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR which interacts with the neuroprotective peptide humanin (PubMed:19386761).

Molecular function

Receptor

More Types Infomation

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