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COL4A3
Anti-COL4A3 Recombinant Antibody Products
- Human Anti-COL4A3 Recombinant Antibody (clone 2D6) (FAMAB-0340JF)
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- Species Reactivity: Bovine
- Type: Human IgM, λ
- Application: ELISA, FuncS
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- Human Anti-COL4A3 Recombinant Antibody (clone 2D6); Fab Fragment (FAMAB-0340JF-F(E))
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- Species Reactivity: Bovine
- Type: Human Fab
- Application: ELISA, FuncS
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- Human Anti-COL4A3 Recombinant Antibody (clone 2D6); scFv Fragment (FAMAB-0340JF-S(P))
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- Species Reactivity: Bovine
- Type: Human scFv
- Application: ELISA, FuncS
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For Research Use Only. Not For Clinical Use.
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a chicken-wire meshwork together with laminins, proteoglycans and entactin/nidogen
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Cone photoreceptor cells, Alveolar cells type 1, Muller glia cells, Oligodendrocyte precursor cells, Bipolar cells)
Immune cell specificity
Immune cell enhanced (memory B-cell)
Cell line specificity
Cell line enhanced (HeLa, hTERT-RPE1, Karpas-707, RPTEC TERT1, U-266/70)
Interaction
There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. The alpha 3(IV) chain forms a triple helical protomer with alpha 4(IV) and alpha 5(IV); this triple helical structure dimerizes through NC1-NC1 domain interactions such that the alpha 3(IV), alpha 4(IV) and alpha 5(IV) chains of one protomer connect with the alpha 5(IV), alpha 4(IV) and alpha 3(IV) chains of the opposite promoter, respectively (PubMed:12193605). Interacts with ITGB3 (PubMed:12682293). Associates with LAMB2 at the neuromuscular junction and in GBM (By similarity).
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