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    CREB1

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    For Research Use Only. Not For Clinical Use.


    CREB1 (CAMP Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with CREB1 include Histiocytoma, Angiomatoid Fibrous and Melanoma Of Soft Tissue. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and enzyme binding. An important paralog of this gene is CREM.
    Protein class

    Cancer-related genes, Disease related genes, Transcription factors

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enriched (Early spermatids)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Low cell line specificity

    Interaction

    Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-119, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1. Interacts with TSSK4; this interaction facilitates phosphorylation on Ser-119 (PubMed:15964553). Forms a complex with KMT2A and CREBBP (PubMed:23651431). (Microbial infection) Interacts with hepatitis B virus/HBV protein X. (Microbial infection) Interacts with HTLV-1 protein Tax.

    Molecular function

    Activator, DNA-binding

    More Types Infomation
    Related Signaling Pathways
    cAMP Signaling Pathway cAMP Signaling Pathway
    MAPK Signaling Pathway MAPK Signaling Pathway
    PPAR Signaling Pathway PPAR Signaling Pathway
    TLR Signaling Pathway TLR Signaling Pathway
    TNF Signaling Pathway TNF Signaling Pathway
    Related Diseases
    Prostate Cancer Prostate Cancer
    Morphine Addiction Morphine Addiction
    Cocaine Addiction Cocaine Addiction
    Amphetamine Addiction Amphetamine Addiction
    Alcoholism Alcoholism
    Cushing Syndrome Cushing Syndrome
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