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CREB1

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Anti-CREB1 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells
Protein class

Cancer-related genes, Disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Early spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-119, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1. Interacts with TSSK4; this interaction facilitates phosphorylation on Ser-119 (PubMed:15964553). Forms a complex with KMT2A and CREBBP (PubMed:23651431). (Microbial infection) Interacts with hepatitis B virus/HBV protein X. (Microbial infection) Interacts with HTLV-1 protein Tax.

Molecular function

Activator, DNA-binding

More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway cAMP Signaling Pathway
MAPK Signaling Pathway MAPK Signaling Pathway
PPAR Signaling Pathway PPAR Signaling Pathway
TLR Signaling Pathway TLR Signaling Pathway
TNF Signaling Pathway TNF Signaling Pathway
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Morphine Addiction Morphine Addiction
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Amphetamine Addiction Amphetamine Addiction
Alcoholism Alcoholism
Cushing Syndrome Cushing Syndrome
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