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CRLF2

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL.
Protein class

Cancer-related genes, Human disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enriched (monocytes)

Immune cell specificity

Immune cell enriched (plasmacytoid DC)

Cell line specificity

Cell line enriched (HMC-1)

Interaction

Heterodimer of CRLF2 and IL7R.

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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