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CRTAM
Anti-CRTAM Recombinant Antibody Products
- Mouse Anti-CRTAM Recombinant Antibody (clone 17B2) (HPAB-1089-FY)
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- Derivation: Chimeric (hamster/mouse)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, FC
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- Human Anti-CRTAM Recombinant Antibody (VS-0723-WK81) (VS-0723-WK81)
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG1
- Application: FC
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- Human Anti-CRTAM Recombinant Antibody (VS-0723-WK71) (VS-0723-WK71)
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG1
- Application: FC
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- Hamster Anti-CRTAM Recombinant Antibody (clone 17B2); scFv Fragment (HPAB-1089-FY-F(E))
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- Species Reactivity: Human
- Type: Hamster scFv
- Application: WB, FC
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- Mouse Anti-CRTAM Recombinant Antibody (clone 17B2); Fab Fragment (HPAB-1089-FY-S(P))
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- Derivation: Chimeric (hamster/mouse)
- Species Reactivity: Human
- Type: Chimeric(hamster/mouse) Fab
- Application: WB, FC
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For Research Use Only. Not For Clinical Use.
CRTAM is a gene that encodes a cell surface protein found on certain immune cells, particularly T cells. This protein plays a role in the interaction between cytotoxic T lymphocytes (CTLs) and tumor cells or infected cells, enhancing immune responses. CRTAM also aids in the regulation of T cell functions, contributing to both the immune response against pathogens and the regulation of autoimmunity. Its expression is often upregulated during inflammation and may be involved in chronic inflammatory diseases or cancer.
Protein class
CD markers
Predicted location
Membrane
Single cell type specificity
Group enriched (dendritic cells, T-cells, Plasma cells)
Immune cell specificity
Immune cell enhanced (NK-cell)
Cell line specificity
Cell line enriched (SCLC-21H)
Interaction
Monomer (PubMed:23583034). May form homodimer (via Ig-like V-type domain) (PubMed:23583034, PubMed:23871486). Interacts (via Ig-like V-type domain) with CADM1 (via Ig-like V-type domain); the interaction competes with CRTAM homodimerization and CADM1 homodimerization (PubMed:15781451, PubMed:15811952, PubMed:23871486). Interacts (via PDZ-binding motif) with SCRIB (via PDZ domain 3); the interaction promotes CRTAM and SCRIB polarization in a subset of CD4+ T-cells (By similarity).
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