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CRTAM
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008).
Protein class
CD markers
Predicted location
Membrane
Single cell type specificity
Group enriched (dendritic cells, T-cells, Plasma cells)
Immune cell specificity
Immune cell enhanced (NK-cell)
Cell line specificity
Cell line enriched (SCLC-21H)
Interaction
Monomer (PubMed:23583034). May form homodimer (via Ig-like V-type domain) (PubMed:23583034, PubMed:23871486). Interacts (via Ig-like V-type domain) with CADM1 (via Ig-like V-type domain); the interaction competes with CRTAM homodimerization and CADM1 homodimerization (PubMed:15781451, PubMed:15811952, PubMed:23871486). Interacts (via PDZ-binding motif) with SCRIB (via PDZ domain 3); the interaction promotes CRTAM and SCRIB polarization in a subset of CD4+ T-cells (By similarity).
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
- Human Anti-CRTAM Recombinant Antibody (VS-0723-WK81) (VS-0723-WK81)
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG1
- Application: FC
- Human Anti-CRTAM Recombinant Antibody (VS-0723-WK71) (VS-0723-WK71)
-
- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG1
- Application: FC
- Mouse Anti-CRTAM Recombinant Antibody (clone 17B2) (HPAB-1089-FY)
-
- Derivation: Chimeric (hamster/mouse)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, FC
- Hamster Anti-CRTAM Recombinant Antibody (clone 17B2); scFv Fragment (HPAB-1089-FY-F(E))
-
- Species Reactivity: Human
- Type: Hamster scFv
- Application: WB, FC
- Mouse Anti-CRTAM Recombinant Antibody (clone 17B2); Fab Fragment (HPAB-1089-FY-S(P))
-
- Derivation: Chimeric (hamster/mouse)
- Species Reactivity: Human
- Type: Chimeric(hamster/mouse) Fab
- Application: WB, FC
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For Research Use Only. Not For Clinical Use.