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CRX

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For Research Use Only. Not For Clinical Use.


Background

CRX (Cone-Rod Homeobox) is a Protein Coding gene. Diseases associated with CRX include Cone-Rod Dystrophy 2 and Leber Congenital Amaurosis 7. Among its related pathways are Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is OTX2.
Protein class

Disease related genes, Human disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Group enriched (Rod photoreceptor cells, Cone photoreceptor cells, Bipolar cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Not detected

Interaction

Interacts (via the homeobox) with NRL (via the leucine-zipper domain). Interacts with PDC, RAX2, RORB and SCA7.

Molecular function

Activator, Developmental protein, DNA-binding

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