Anti-CTNNB1 Recombinant Antibody Products

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Anti-CTNNB1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is proud to be at the forefront of cancer and developmental biology research, and is a trusted source for premium anti-CTNNB1 recombinant antibodies. Beta-catenin (CTNNB1) is a master transcriptional co-activator that serves as the core effector of the canonical Wnt signaling pathway, and has a critical role in cell adhesion. Our highly specific and validated antibodies are essential to investigations into embryogenesis and tissue homeostasis, as well as the oncogenic mechanisms resulting from its dysregulation.

CTNNB1: The Heart of the Wnt Signaling Pathway

Catenin Beta 1 (CTNNB1), commonly known as beta-catenin, is a protein with two very important roles. As a part of adherens junctions at the cell membrane, it binds cadherins to the actin cytoskeleton to promote cell-cell adhesion. In the cytoplasm and nucleus, it is the central effector of the canonical Wnt signaling pathway. Beta-catenin is perpetually phosphorylated by a “destruction complex” and targeted for proteosomal degradation in the absence of a Wnt signal. This destruction complex is inactivated by Wnt signaling, and allows for beta-catenin to accumulate, translocate into the nucleus, and act as a transcriptional co-activator to promote the expression of target genes involved in cell proliferation and cell fate. Activating mutations in CTNNB1 are a significant oncogenic driver in many cancers, most notably colorectal and liver cancer.

Alternative Names

EVR7; CTNNB; MRD19; NEDSDV; armadillo; catenin beta-1; catenin (cadherin-associated protein), beta 1, 88kDa

Background

CTNNB1, encoding β-catenin, is a multifunctional protein that plays a dual and critical role in cellular biology: it acts as a central component of cadherin-based adherens junctions for cell-cell adhesion and is the key effector molecule of the canonical Wnt signaling pathway, regulating gene transcription. The tight regulation of β-catenin's stability and subcellular localization, predominantly controlled by its phosphorylation status, is therefore paramount for maintaining cellular homeostasis, development, and preventing disease.

β-Catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer.

Anti-CTNNB1 rAb Products

Creative Biolabs’ anti-CTNNB1 recombinant antibodies are designed for ultimate specificity and outstanding performance. We provide both total beta-catenin antibodies as well as phospho-specific antibodies that target the inactive, phosphorylated form. Optimized for Western Blot and IHC to detect oncogenic nuclear accumulation, as well as co-immunoprecipitation, our rAbs are some of the best tools available to study the Wnt signaling pathway.

Table 1. Featured anti-CTNNB1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Quality is at the heart of everything we do at Creative Biolabs, and our anti-CTNNB1 recombinant antibodies are no exception. Their production is tightly controlled by an internal quality assurance system. Each lot is extensively tested for purity, specificity, and consistent performance on validated cell models before shipment, so you can be sure you are getting a reliable reagent for your important experiments.

Customer Reviews

Excellent

K**ra

The Creative Biolabs anti-beta-catenin antibody is excellent for IHC. We see a very clear staining pattern of aberrant nuclear accumulation in our colorectal cancer cell lines. A quality standard reagent.

19/Mar/2024

rAb Production

Creative Biolabs is committed to propelling research in cancer and developmental biology forward as quickly as possible. With the latest production technologies at our disposal, our anti-CTNNB1 recombinant antibodies, including our panel of phospho-specifics, are carefully crafted to ensure the highest possible specificity and sensitivity.

Featured Anti-CTNNB1 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-CTNNB1 recombinant antibody production.

Fig.4 Gram-scale anti-CTNNB1 recombinant antibody production.

rAb Modalities

We strive to provide the research community with the most versatile and cutting-edge tools possible. Our anti-CTNNB1 recombinant antibodies are no exception, being offered in a wide variety of formats to support many different experimental modalities to study this central oncogenic pathway.

Fig.5 Full-length anti-CTNNB1 recombinant antibody production and modalities.

Need to drive your Wnt signaling studies forward? Creative Biolabs has some of the best anti-CTNNB1 recombinant antibodies available, defined by their exceptional specificity and extensive validation to be the ideal tools for cancer drug discovery and developmental biology research. Let our expertise help you with your important work, and contact our specialists today.

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