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CXCL12
Anti-CXCL12 Recombinant Antibody Products
- Human Anti-CXCL12 Antibody, mRNA (TAB-199CL-mRNA)
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- Species Reactivity: Human
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- Human Anti-CXCL12 Recombinant Antibody (HPAB-632-FY) (HPAB-632-FY)
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- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human, Mouse
- Type: Chimeric (Mouse/Human) IgG2a
- Application: Inhib
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- Human Anti-CXCL12 Recombinant Antibody (HPAB-633-FY) (HPAB-633-FY)
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- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human, Mouse
- Type: Chimeric (Mouse/Human) IgG2a
- Application: Block
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- Rabbit Anti-CXCL12 Polyclonal Antibody (MRO-1795-CN) (MRO-1795-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, FC
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- Human Anti-CXCL12 Recombinant Antibody (HPAB-0052LY) (HPAB-0052LY)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: Block, ELISA, WB, RIA, FC
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- Human Anti-CXCL12 Recombinant Antibody (HPAB-0053LY) (HPAB-0053LY)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: Block, ELISA, WB, RIA, FC
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- Recombinant Anti-human CXCL12 Antibody (MOB-256)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, FC, FuncS
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- Anti-Human CXCL12 Recombinant Antibody Fab Fragment (hu30D8) (TAB-416CT-F(E))
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- Species Reactivity: Mouse and Human CXCL12α, CXCL12β, and CXCL12γ
- Type: Humanized antibody
- Application: WB, ELISA, Neut, FC
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- Derivation: Transgenic Mouse
- Species Reactivity: Human
- Type: Human Fab
- Application: BL, WB, ELISA
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- Derivation: Transgenic Mouse
- Species Reactivity: Human
- Type: Human Fab
- Application: BL, WB, ELISA
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- Derivation: Transgenic Mouse
- Species Reactivity: Human
- Type: Human Fab
- Application: BL, WB, ELISA
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- Derivation: Transgenic Mouse
- Species Reactivity: Human
- Type: Human Fab
- Application: BL, WB, ELISA
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- Anti-Human CXCL12 Recombinant Antibody scFv Fragment (hu30D8) (TAB-416CT-S(P))
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- Species Reactivity: Mouse and Human CXCL12α, CXCL12β, and CXCL12γ
- Type: Humanized antibody
- Application: WB, ELISA, Neut, FC
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- Derivation: Transgenic Mouse
- Species Reactivity: Human
- Type: Human scFv
- Application: BL, WB, ELISA
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- Derivation: Transgenic Mouse
- Species Reactivity: Human
- Type: Human scFv
- Application: BL, WB, ELISA
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- Derivation: Transgenic Mouse
- Species Reactivity: Human
- Type: Human scFv
- Application: BL, WB, ELISA
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- Derivation: Transgenic Mouse
- Species Reactivity: Human
- Type: Human scFv
- Application: BL, WB, ELISA
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- Anti-Human CXCL12 Recombinant Antibody (hu30D8) (TAB-416CT)
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- Species Reactivity: Mouse and Human CXCL12α, CXCL12β, and CXCL12γ
- Type: Humanized antibody
- Application: Funcs, FC, PK, ELISA, Neut, WB
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- Derivation: Transgenic Mouse
- Species Reactivity: Human
- Type: Human IgG
- Application: BL, WB, ELISA
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- Derivation: Transgenic Mouse
- Species Reactivity: Human
- Type: Human IgG
- Application: BL, WB, ELISA
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- Derivation: Transgenic Mouse
- Species Reactivity: Human
- Type: Human IgG
- Application: BL, WB, ELISA
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- Derivation: Transgenic Mouse
- Species Reactivity: Human
- Type: Human IgG
- Application: BL, WB, ELISA
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- Anti-Human CXCL12 Recombinant Antibody (TAB-199CL)
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- Derivation: Human
- Species Reactivity: Human
- Type: Antibody
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- Human Anti-CXCL12 Recombinant Antibody (HPAB-0050LY) (HPAB-0050LY)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: Block, ELISA, WB, RIA, FC
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- Human Anti-CXCL12 Recombinant Antibody (HPAB-0051LY) (HPAB-0051LY)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: Block, ELISA, WB, RIA, FC
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- Anti-Human CXCL12 Recombinant Antibody Fab Fragment (30D8) (TAB-415CT-F(E))
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- Species Reactivity: Mouse and Human CXCL12α, CXCL12β, and CXCL12γ
- Application: WB, ELISA, Neut, FC
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- Llama Anti-CXCL12 Recombinant Antibody; VHH Fragment (HPAB-0348-YC-VHH) (HPAB-0348-YC-VHH)
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- Species Reactivity: Human
- Type: Llama VHH
- Application: FuncS
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- Recombinant Human Anti-human CXCL12 Antibody scFv Fragment (MHH-256-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
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- Anti-Human CXCL12 Recombinant Antibody (30D8) (TAB-415CT)
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- Species Reactivity: Mouse and Human CXCL12α, CXCL12β, and CXCL12γ
- Application: Inhib, WB, FC, Funcs, ELISA, Neut
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- Anti-Human CXCL12 Recombinant Antibody scFv Fragment (30D8) (TAB-415CT-S(P))
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- Species Reactivity: Mouse and Human CXCL12α, CXCL12β, and CXCL12γ
- Application: WB, ELISA, Neut, FC
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- Recombinant Human Anti-human CXCL12 Antibody Fab Fragment (MHH-256-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
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- Recombinant Anti-human CXCL12 Antibody Fab Fragment (MOB-256-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IF, FACS, FuncS
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- Recombinant Anti-human CXCL12 Antibody scFv Fragment (MOB-256-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: IP, IF, Biosensors, FuncS
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- Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-0050LY-S(P)) (HPAB-0050LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: Block, ELISA, WB, RIA, FC
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- Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-0051LY-S(P)) (HPAB-0051LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: Block, ELISA, WB, RIA, FC
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- Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-0052LY-S(P)) (HPAB-0052LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: Block, ELISA, WB, RIA, FC
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- Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-0053LY-S(P)) (HPAB-0053LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: Block, ELISA, WB, RIA, FC
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- Mouse Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-632-FY-S(P)) (HPAB-632-FY-S(P))
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- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: Inhib
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- Mouse Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-633-FY-S(P)) (HPAB-633-FY-S(P))
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- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: Block
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- Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (HPAB-632-FY-F(E)) (HPAB-632-FY-F(E))
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- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human, Mouse
- Type: Chimeric (Mouse/Human) Fab
- Application: Inhib
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- Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (HPAB-633-FY-F(E)) (HPAB-633-FY-F(E))
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- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human, Mouse
- Type: Chimeric (Mouse/Human) Fab
- Application: Block
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- Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (HPAB-0050LY-F(E)) (HPAB-0050LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: Block, ELISA, WB, RIA, FC
Compare
- Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (HPAB-0051LY-F(E)) (HPAB-0051LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: Block, ELISA, WB, RIA, FC
Compare
- Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (HPAB-0052LY-F(E)) (HPAB-0052LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: Block, ELISA, WB, RIA, FC
Compare
- Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (HPAB-0053LY-F(E)) (HPAB-0053LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: Block, ELISA, WB, RIA, FC
Compare
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For Research Use Only. Not For Clinical Use.
This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Fibroblasts, Adipocytes, Kupffer cells, Distal tubular cells, Smooth muscle cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC diff, BJ hTERT+, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, fHDF/TERT166, HSkMC)
Interaction
Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N-terminus of ACKR3. Interacts with integrin subunit ITGB3 (via the allosteric site (site 2)) (PubMed:29301984). Interacts with TNFAIP6 (via Link domain). (Microbial infection) Interacts with molluscum contagiosum virus protein MC148.
Molecular function
Cytokine, Growth factor
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