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CACNB2
CACNB2 (Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2) is a Protein Coding gene. This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Diseases associated with CACNB2 include Brugada Syndrome 4 and Lambert-Eaton Myasthenic Syndrome.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Predicted location
Intracellular
Single cell type specificity
Group enriched (Astrocytes, Excitatory neurons, Inhibitory neurons)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HAP1, HSkMC)
Interaction
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2. Interacts with CACNA1C (By similarity). Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane (PubMed:17525370). Interacts with TMIGD2 (PubMed:22419821). Interacts with CAMK2D. Interacts with CBARP (By similarity). Interacts with CAMK2A (PubMed:28130356).
Molecular function
Calcium channel, Ion channel, Voltage-gated channel
More Types Infomation
- Mouse Anti-CACNB2 Recombinant Antibody (clone 6C4) (MOB-1948MZ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IHC, IP, FuncS
- Rabbit Anti-CACNB2 Recombinant Antibody (clone rN8B/1R) (VS-0422-LC47)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: IF
- Human Anti-CACNB2 Recombinant Antibody (clone hN8B/1R) (VS-0422-LC46)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: IF
- Rat Anti-CACNB2 Recombinant Antibody (clone rtN8B/1R) (VS-0422-LC45)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: IF
- Mouse Anti-CACNB2 Recombinant Antibody (clone mN8B/1R) (VS-0422-LC44)
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- Species Reactivity: Rat, Human, Mouse
- Type: Mouse IgG2a
- Application: IF
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For Research Use Only. Not For Clinical Use.