Anti-Casp1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs has you covered when it comes to immunology and inflammation research! We can provide highly specific and validated anti-CASP1 recombinant antibodies to suit your needs. Caspase-1 (CASP1) is a prototypical inflammatory caspase and the motor of the inflammasome, the master initiator of the innate immune response. Our premium antibodies can help you study pyroptosis, the processing of critical cytokines, and the development of novel anti-inflammatory therapeutics.

CASP1: The Inflammasome's Executioner Enzyme

Caspase-1, also called Interleukin-1 Converting Enzyme (ICE), is a cysteine protease that is a key initiator of inflammation. It is expressed as an inactive proenzyme called pro-caspase-1. In response to pathogen and/or cellular danger signals that are detected by intracellular sensor proteins like NLRP3, large protein platforms known as inflammasomes are formed. Inflammasomes act to recruit and activate pro-caspase-1, which is then activated through dimerization due to proximity with auto-cleavage. Active caspase-1 then performs two critical functions. It cleaves the inflammatory cytokines pro-IL-1beta and pro-IL-18, producing mature, secreted IL-1beta and IL-18. Caspase-1 also cleaves Gasdermin D, which initiates a fiery, lytic form of cell death known as pyroptosis.

Alternative Names

Caspase 1; Caspase 1, Apoptosis-Related Cysteine Peptidase; Interleukin 1, Beta, Convertase; IL-1 Beta-Converting Enzyme; EC 3.4.22.36; Caspase-1; IL1BC; P45; ICE; Caspase 1, Apoptosis-Related Cysteine Peptidase (Interleukin 1, Beta, Convertase); Caspase 1, Apoptosis-Related Cysteine Protease (Interleukin 1, Beta, Convertase);

Background

Enables cysteine-type endopeptidase activity. Involved in several processes, including AIM2 inflammasome complex assembly; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of interleukin-1 beta production. Acts upstream of or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of cytokine production. Located in extracellular region. Part of IPAF inflammasome complex. Is active in cytosol. Is expressed in several structures, including forelimb mesenchyme; knee joint; oocyte; small intestine; and telencephalon. Orthologous to human CASP1 (caspase 1).

Anti-CASP1 rAb Products

Creative Biolabs' anti-CASP1 recombinant antibodies are validated to be highly specific and performant. We have carefully tested these antibodies to make sure that they detect both the pro-form of caspase-1 as well as the cleaved, active p20/p10 subunits. We have optimized these antibodies for Western Blot applications to track inflammasome activation, and they have become a gold standard for the field of inflammation research, giving you clear and unambiguous results.

Table 1. Featured anti-CASP1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is proud to provide tools that support the specialized field of immunology with its state-of-the-art antibody production platforms. We express our anti-CASP1 recombinant antibodies in an optimized system to make sure that the antibody can recognize the various forms of the enzyme in question to give you a specific and active tool for your research.

Featured Anti-CASP1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CASP1 recombinant antibody production.

Fig.2 Gram-scale anti-CASP1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to facilitating scientific discovery by providing antibody solutions that allow for flexibility. Our anti-CASP1 recombinant antibodies are offered in several formats so that researchers around the world can study this critical inflammatory enzyme in their specific systems.

Fig.3 Full-length anti-CASP1 recombinant antibody production and modalities.

Gain a clearer understanding of inflammasome activation with Creative Biolabs' anti-CASP1 recombinant antibodies. We offer the validation and lot-to-lot consistency required for studying this highly therapeutically relevant target in inflammatory disease. Let us lay the groundwork for your research; contact our scientific team today.