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CD109

CD109 (CD109 Molecule) is a Protein Coding gene. Diseases associated with CD109 include Fetal And Neonatal Alloimmune Thrombocytopenia and Vulva Squamous Cell Carcinoma. Among its related pathways are Metabolism of proteins and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and transforming growth factor beta binding. An important paralog of this gene is CPAMD8.
Protein class

CD markers, Plasma proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Adipocytes, Basal respiratory cells, Squamous epithelial cells, Hofbauer cells, Suprabasal keratinocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC TERT1, BJ hTERT+)

Interaction

Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner.

Molecular function

Protease inhibitor, Serine protease inhibitor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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