Cancer-related genes, Enzymes
Intracellular
Cell type enhanced (Langerhans cells, Urothelial cells)
Immune cell enriched (neutrophil)
Cell line enhanced (U-266/70)
TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and CASP8 (PubMed:9880531). A proteolytic fragment (p43) stays associated with the DISC (PubMed:9880531). Also interacts with FADD, CASP8, CASP3, TRAF1, TRAF2 and Bcl-X(L) (in vitro) (PubMed:9326610, PubMed:9208847). Interacts with RIPK1 (By similarity) (PubMed:9326610, PubMed:9208847, PubMed:9880531). (Microbial infection) Interacts with HBV protein X.
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For Research Use Only. Not For Clinical Use.