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CFLAR

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8.
Protein class

Cancer-related genes, Enzymes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Langerhans cells, Urothelial cells)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Cell line enhanced (U-266/70)

Interaction

TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and CASP8 (PubMed:9880531). A proteolytic fragment (p43) stays associated with the DISC (PubMed:9880531). Also interacts with FADD, CASP8, CASP3, TRAF1, TRAF2 and Bcl-X(L) (in vitro) (PubMed:9326610, PubMed:9208847). Interacts with RIPK1 (By similarity) (PubMed:9326610, PubMed:9208847, PubMed:9880531). (Microbial infection) Interacts with HBV protein X.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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