CLEC9A

CLEC9A is a C-type lectin receptor predominantly expressed on dendritic cells, particularly those in tissues such as the spleen and lymph nodes. It is involved in the recognition of necrotic cell debris, which contains specific markers that trigger immune responses. CLEC9A has a key role in activating dendritic cells, leading to the initiation of adaptive immune responses, particularly in response to intracellular pathogens like viruses. By engaging with its ligands, CLEC9A helps shape the immune response and is being studied as a potential target for enhancing vaccine responses and immunotherapies.