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DAPK1

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Protein class

Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Inhibitory neurons, Astrocytes, Excitatory neurons, Kupffer cells)

Immune cell specificity

Group enriched (non-classical monocyte, intermediate monocyte, eosinophil, classical monocyte, plasmacytoid DC, myeloid DC)

Cell line specificity

Cell line enhanced (HMC-1, HUVEC TERT2)

Interaction

Interacts with KLHL20 (PubMed:20389280). Interacts (via death domain) with MAPK1 and MAPK3 (PubMed:15616583). Interacts with MAP1B (via N-terminus) (PubMed:18195017). Interacts with PRKD1 in an oxidative stress-regulated manner (PubMed:17703233). Interacts with PIN1, PDCD6, BECN1, TSC2 and STX1A (PubMed:12730201, PubMed:16132846, PubMed:18974095, PubMed:19180116, PubMed:21497122). Interacts (via kinase domain) with DAPK3 (via kinase domain) (PubMed:15367680). Interacts with GRINB (By similarity). Interacts (via death domain) with UNC5B (via death domain) (PubMed:15729359). Interacts with UNC5C (via death domain) (PubMed:27068745).

Molecular function

Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase

More Types Infomation

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