+ Filter
Loading...
Anti-DDC Recombinant Antibody Products
Loading...Anti-DDC Products
- Mouse Anti-DDC Recombinant Antibody (clone 27F8) (MOB-2355z)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: ELISA, WB, IP
Compare
- Rabbit Anti-DDC Recombinant Antibody (clone JA53-16) (MRO-0490-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
Compare
- Anti-DDC Immunohistochemistry Kit (VS-0325-XY636)
-
- Species Reactivity: Human, Mouse, Rat
- Target: DDC
- Application: IHC
Compare
- Anti-Mouse DDC Immunohistochemistry Kit (VS-0525-XY1941)
-
- Species Reactivity: Human, Mouse, Rat
- Target: DDC
- Application: IHC
Compare
- Anti-Human DDC Immunohistochemistry Kit (VS-0525-XY1940)
-
- Species Reactivity: Human
- Target: DDC
- Application: IHC
Compare
- Chicken Anti-DDC (ab1) Polyclonal IgY (BRD-0156MZ)
-
- Species Reactivity: Human
- Type: Chicken antibody
- Application: indirect ELISA, WB
Compare
- Chicken Anti-DDC (ab2) Polyclonal IgY (BRD-0157MZ)
-
- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
Compare
View More Products
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
Creative Biolabs is your dedicated neuroscience and metabolic disease antibody development partner. We are here to assist you in your research projects with premier anti-DDC (AADC) recombinant antibodies. Dopa Decarboxylase (DDC/AADC) is an enzyme that helps to synthesize dopamine and serotonin in the body, which are neurotransmitters that relay information throughout the brain. Check out our high-quality antibodies for investigating Parkinson's, AADC deficiency, and regulation of neurotransmitter synthesis.
DDC: The Final Step in Dopamine and Serotonin Synthesis
Dopa Decarboxylase (DDC), also known as Aromatic L-amino acid decarboxylase (AADC), is an enzyme located in the cytosol of a cell. It is responsible for the final step in the synthesis of two important monoamine neurotransmitters. DDC can catalyze both L-DOPA to dopamine and 5-hydroxytryptophan (5-HTP) to serotonin. This step is critical for proper motor function and neurotransmission. Loss of AADC due to genetic mutation causes a devastating, infantile onset movement disorder. In Parkinson's disease, inhibition of DDC is a mechanism by which L-DOPA, a dopamine precursor, can be used to maintain normal levels of dopamine.
Alternative Names
DDC; DOPA Decarboxylase; Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase); EC 4.1.1.28; EC 4.1.1
Background
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Rod photoreceptor cells, Proximal tubular cells, Enteroendocrine cells, Proximal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (CACO-2, Hep G2, OE19, SCLC-21H, SH-SY5Y)
Interaction
Homotetramer.
Molecular function
Decarboxylase, Lyase
More Types Infomation
Anti-DDC rAb Products
Our anti-DDC recombinant antibodies are produced to provide high specificity and strong performance. The antibody is stringently validated to specifically recognize DDC in brain and other neuronal tissues. Optimized for IHC and Western Blot, these rAbs will offer you the performance and reliability to explore the inner-workings of dopamine and serotonin synthesis.
Table 1. Featured anti-DDC recombinant antibody products at Creative Biolabs.
| Cat. No. | Product Name | Target Species | Host Species | Applications |
| MOB-2355z | Mouse Anti-DDC Recombinant Antibody (clone 27F8) | Human | Mouse IgG2a, κ | ELISA, WB, IP |
| MOB-2458CT | Recombinant Mouse anti-Cow DDC Monoclonal antibody (40B6) | Cow | Mouse IgG | ICC/IF, WB, IP, ELISA |
| MRO-0490-CN | Rabbit Anti-DDC Recombinant Antibody (clone JA53-16) | Human | Rabbit IgG | WB, IHC |
Customer Reviews
Excellent
El**nMouse Anti-DDC Recombinant Antibody (clone 27F8)
I used the anti-DDC antibody from Creative Biolabs in our project on Parkinson's disease. The IP staining of substantia nigra sections was specific and easily allowed visualization of dopaminergic neurons.
28/Oct/2023
Excellent
Pa**eRabbit Anti-DDC Recombinant Antibody (clone JA53-16)
We are working on validating a gene therapy approach for AADC deficiency, and this antibody has been very helpful for us to confirm protein expression after treatment by Western blot. The quality of this antibody is excellent.
27/Sep/2024
rAb Production
Creative Biolabs specializes in the use of next-generation production platforms to make recombinant antibodies for complex biology. Our anti-DDC recombinant antibodies are expressed in highly optimized systems that are engineered to make antibodies that accurately recognize the native enzyme, providing a very specific and active antibody for your demanding applications.
Featured Anti-DDC Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-DDC recombinant antibody production.
Fig.2 Gram-scale anti-DDC recombinant antibody production.
rAb Modalities
Creative Biolabs is committed to advancing science, and in order to do so we must provide scientists with the tools they need to do their best work. Our anti-DDC recombinant antibodies are available in a range of customizable modalities, allowing researchers across the globe to work on this important enzyme in both rare diseases and more common neurological conditions.
Fig.3 Full-length anti-DDC recombinant antibody production and modalities.
Partner with Creative Biolabs and explore the important role DDC plays in neurotransmitter synthesis with our high-quality recombinant antibodies. We pride ourselves on high specificity and rigorous validation, making our portfolio the ideal set of tools for your neuroscience research projects. Contact our experts today.
