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DKK1
This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines.
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Prostatic glandular cells, Basal prostatic cells, Endometrial stromal cells, Urothelial cells, Pancreatic endocrine cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, CACO-2, fHDF/TERT166)
Interaction
Interacts with LRP6 (PubMed:11448771, PubMed:17804805, PubMed:20093360, PubMed:22000856). Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling (PubMed:19746449). Forms a ternary complex with LRP6 and KREM1 (PubMed:27524201). Interacts with KREM1 (PubMed:17804805).
Molecular function
Developmental protein
More Types Infomation
Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
- Rabbit Anti-DKK1 Recombinant Antibody (clone CBACN-197) (MRO-0479-CN)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
- Rabbit Anti-DKK1 Polyclonal Antibody (MRO-1816-CN) (MRO-1816-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Species Reactivity: Human
- Application: WB
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: Neut
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Derivation: Chimeric (mouse/rat)
- Species Reactivity: Rat
- Type: Chimeric (mouse/rat) IgG
- Application: ELISA
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, IF, IHC-P, WB
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: Neut
- Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-670-FY-S(P)) (HPAB-670-FY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
- Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0107-FY-S(P)) (HPAB-0107-FY-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS
- Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0761-FY-S(P)) (HPAB-0761-FY-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0280-YC-S(P)) (HPAB-0280-YC-S(P))
-
- Species Reactivity: Human, Mouse, Monkey
- Type: Human scFv
- Application: ELISA
- Anti-Human DKK1 Recombinant Antibody (4E4hum 7) (TAB-013MZ-VHH)
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- Type: Single domain antibody
- Application: ELISA
- Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0096-FY-S(P)) (HPAB-0096-FY-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS
- Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0760-FY-S(P)) (HPAB-0760-FY-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0279-YC-S(P)) (HPAB-0279-YC-S(P))
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- Species Reactivity: Human, Mouse, Rat, Monkey, Rabbit
- Type: Human scFv
- Application: Block, FuncS
- Anti-Human DKK1 Recombinant Antibody (16A12) (TAB-012MZ-VHH)
-
- Derivation: Phage library
- Type: Single domain antibody
- Application: ELISA
- Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0280-YC-F(E)) (HPAB-0280-YC-F(E))
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- Species Reactivity: Human, Mouse, Monkey
- Type: Human Fab
- Application: ELISA
- Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0759-FY-S(P)) (HPAB-0759-FY-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0278-YC-S(P)) (HPAB-0278-YC-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Block, FuncS
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