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DKK2
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Fibroblasts, Hofbauer cells, Langerhans cells, Basal keratinocytes, Suprabasal keratinocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (SH-SY5Y)
Interaction
Interacts with LRP5 and LRP6.
Molecular function
Developmental protein
More Types Infomation
Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
- Mouse Anti-DKK2 Recombinant Antibody (VS3-WK1189) (VS3-WK1189)
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1, κ
- Application: WB
- Human Anti-DKK2 Recombinant Antibody (HPAB-0057CQ) (HPAB-0057CQ)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1, κ
- Application: ELISA, FC, Neut
- Human Anti-DKK2 Recombinant Antibody; scFv Fragment (HPAB-0057CQ-S(P)) (HPAB-0057CQ-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, Neut
- Human Anti-DKK2 Recombinant Antibody; Fab Fragment (HPAB-0057CQ-F(E)) (HPAB-0057CQ-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC, Neut
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For Research Use Only. Not For Clinical Use.