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DOK5
Anti-DOK5 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes, Inhibitory neurons, Muller glia cells, Oligodendrocyte precursor cells, Excitatory neurons, Distal tubular cells, Horizontal cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced
Interaction
Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP (By similarity).
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