+ Filter
Loading...
DOK5
Loading...Anti-DOK5 Products
CompareCan't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes, Inhibitory neurons, Muller glia cells, Oligodendrocyte precursor cells, Excitatory neurons, Distal tubular cells, Horizontal cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced
Interaction
Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP (By similarity).
More Types Infomation