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DPH1
Anti-DPH1 Recombinant Antibody Products
- Rabbit Anti-DPH1 Antibody (VS-0722-YJ164) (VS1-YJ164)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Rabbit Anti-DPH1 Antibody (VS-0722-YJ165) (VS1-YJ165)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is an enzyme involved in the biosynthesis of diphthamide, a modified histidine found only in elongation factor-2 (EEF2). Diphthamide residues in EEF2 are targeted for ADP-ribosylation by diphtheria toxin and Pseudomonas exotoxin A. Defects in this gene have been associated with both ovarian cancer and autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies.
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Gastric mucus-secreting cells, Basal squamous epithelial cells, Squamous epithelial cells, Plasma cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with DPH2 (By similarity). Interacts with RBM8A.
Molecular function
Transferase
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