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DUS2
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene.
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Late spermatids, Syncytiotrophoblasts, Spermatocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with EPRS1. Interacts (via DRBM domain) with PRKRA and EIF2AK2/PKR (via DRBM 1 domain).
Molecular function
Oxidoreductase, RNA-binding
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