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EDN2

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For Research Use Only. Not For Clinical Use.


This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants.
Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Basal prostatic cells, Club cells, Basal respiratory cells, Proximal enterocytes, Collecting duct cells, Prostatic glandular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (CAPAN-2, EFO-21, HeLa, SCLC-21H, SK-BR-3, U-2 OS)

Molecular function

Vasoactive, Vasoconstrictor

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