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EMILIN1

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For Research Use Only. Not For Clinical Use.


Background

Protein class

Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Peritubular cells, Fibroblasts, Leydig cells, Sertoli cells, Endometrial stromal cells, Smooth muscle cells, Hepatic stellate cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BJ, BJ hTERT+, HHSteC, HSkMC, SH-SY5Y, U-138 MG)

Interaction

Homotrimer associated through a moderately stable interaction of the C-terminal globular C1q domains, allowing the nucleation of the triple helix and then a further quaternary assembly to higher-order polymers via intermolecular disulfide bonds. Interacts with EMILIN2. Interacts with EFEMP2; this interaction promotes the incorporation of EFEMP2 into the extracellular matrix (By similarity).

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