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EPO

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For Research Use Only. Not For Clinical Use.


Background

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.
Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Hepatocytes, Extravillous trophoblasts, Exocrine glandular cells, Pancreatic endocrine cells, Syncytiotrophoblasts, Cytotrophoblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (BEWO, Hep G2)

Molecular function

Hormone

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