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EPO

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EPO encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of EPO has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies.

Derivation:
Fully human phage display
Species Reactivity:
Human, Rat, Mouse, Rabbit, Cynomolgus monkey
Type:
Human Antibody
Application:
ELISA
Species Reactivity:
Human
Type:
Human Antibody
Application:
ELISA, Neut
Derivation:
Fully human phage display
Species Reactivity:
Human, Rat, Mouse, Rabbit, Cynomolgus monkey
Type:
Human Antibody
Application:
ELISA
Species Reactivity:
Human
Type:
Human Antibody
Application:
ELISA, Neut
Species Reactivity:
Human
Type:
IgE, κ
Application:
ELISA, Neut, ELISpot
Species Reactivity:
Human
Type:
IgG1, κ
Application:
ELISA, Neut, ELISpot
Species Reactivity:
Human
Type:
IgG1
Application:
Neut
Species Reactivity:
Mouse
Type:
IgG2
Application:
ELISA, Neut
Species Reactivity:
Mouse
Type:
IgG2
Application:
Neut
Species Reactivity:
Mouse
Type:
IgG2a
Application:
ELISA(Cap), Neut
Species Reactivity:
Mouse
Type:
IgG2a
Application:
Neut
Species Reactivity:
Chinese hamster
Type:
Llama VHH
Application:
WB, ELISA, IHC, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
Fab
Application:
WB, IHC, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Derivation:
Fully human phage display
Species Reactivity:
Human, Rat, Mouse, Rabbit, Cynomolgus monkey
Type:
Human Antibody
Application:
ELISA
Species Reactivity:
Human
Type:
Human Antibody
Application:
ELISA, Neut
Species Reactivity:
Human
Type:
Human IgG4, ĸ
Application:
ELISA, Neut
Species Reactivity:
Human
Application:
ELISA
Species Reactivity:
Human
Application:
ELISA
Species Reactivity:
Human
Application:
ELISA, Neut
Species Reactivity:
Human
Application:
ELISA
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