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    ERBB2 & CD3

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    Anti-ERBB2 & CD3 Products

    • Anti-HER2-Gly5-modified DM1 ADC (ADC-147CL)
      • Target: HER2
      • Drug: Gly5-modified DM1 (Gly5-modified N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-HER2-vcPAB-MMAE ADC (ADC-148CL)
      • Target: HER2
      • Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: MMAE (Monomethyl auristatin E)
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    • Anti-Her2-VCP-cyclooctyne-MMAF ADC (ADC-210CL)
      • Target: Her2
      • Linker: valine-citruline-p-amino-benzoyl-carbonate (VCP)-cyclooctyne
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-DBCO-MMAF ADC (ADC-295CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-DBCO-MMAF ADC (ADC-296CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-DBCO-MMAF ADC (ADC-297CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-DBCO-MMAF ADC (ADC-298CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-DBCO-MMAF ADC (ADC-299CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-248CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-DBCO-MMAF ADC (ADC-300CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-BMPEO-DM1 ADC (ADC-186CL)
      • Target: HER2
      • Linker: BMPEO (bis-maleimido-trioxyethylene glycol)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-HER2-DBCO-MMAF ADC (ADC-307CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-249CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
      Go to compare Compare
    • Anti-HER2-DBCO-MMAF ADC (ADC-308CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-DBCO-MMAF ADC (ADC-309CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-NGMs-MMAE ADC (ADC-035LZY)
      • Target: HER2
      • Linker: NGMs(next generation maleimides)
      • Drug: MMAE (monomethyl auristatin E)
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    • Anti-HER2-SMCC-DM1 ADC (ADC-001LZY)
      • Target: HER2
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-250CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-DBCO-MMAF ADC (ADC-310CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-251CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
      Go to compare Compare
    • Anti-HER2-DBCO-MMAF ADC (ADC-311CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-mc-MMAF ADC (ADC-107LZY)
      • Target: HER2
      • Linker: mc(maleimidocaproyl)
      • Drug: MMAF(monomethyl auristatin F)
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-252CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-DUBA-Duocarmycins ADC (ADC-069LZY)
      • Target: HER2
      • Linker: DUBA (DUocarmycinhydroxyBenzamide-Azaindole
        linker) ("mc"-VC-PABC-CM)
      • Drug: Duocarmycins
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-253CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
      Go to compare Compare
    • Anti-HER2-vc-MMAE ADC (ADC-081LZY)
      • Target: HER2
      • Linker: VC (valine-citrulline)
      • Drug: MMAE(monomethyl auristatin E)
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-254CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-DBM-MMAF ADC (ADC-105LZY)
      • Target: HER2
      • Linker: DBM(dibromomaleimide)
      • Drug: MMAF(monomethyl auristatin F)
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    • Anti-HER2-MP(T-vc)-MMAE ADC (ADC-255CL)
      • Target: HER2
      • Linker: MP(T-VC)
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino) phenylbutanamido)butanamido)hex-2-enamide
      Go to compare Compare
    • Anti-HER2-MC-vc-PABC-MMAE ADC (ADC-256CL)
      • Target: HER2
      • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: (S,E)-N-(4-(aminomethyl)benzylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
      Go to compare Compare
    • Anti-HER2-MT-vc-MMAE ADC (ADC-257CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-DOX ADC (ADC-131LZY)
      • Target: HER2
      • Linker: thiomaleamicacids-p-aminobenzyloxycarbonyl
      • Drug: doxorubicin
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    • Anti-HER2 (trastuzumab)-mcc-DM1 ADC (ADC-129LCT)
      • Target: HER2
      • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
      Go to compare Compare
    • Anti-HER2-MT-vc-MMAE ADC (ADC-258CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
      Go to compare Compare
    • Anti-HER2-SPP-DM1 ADC (ADC-132LZY)
      • Target: HER2
      • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
      Go to compare Compare
    • Anti-HER2-[14C]-SMCC-DM1 ADC (ADC-150LZY)
      • Target: HER2
      • Linker: [14C]-SMCC
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
      Go to compare Compare
    • Anti-Her2-MCC-DM1 ADC (ADC-174LZY)
      • Target: Her2
      • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
      Go to compare Compare
    • Anti-Her2-mc-vc-PABC-MMAE ADC (ADC-175LZY)
      • Target: Her2
      • Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
      • Drug: MMAE (monomethyl auristatin E)
      Go to compare Compare
    • Anti-HER2 (trastuzumab)-SPDP-DM1 ADC (ADC-134LCT)
      • Target: HER2
      • Linker: SPDP ( N-succinimidyl 3-(2-pyridyldithio)propionate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
      Go to compare Compare
    • Anti-HER2 (trastuzumab)-SPP-DM1 ADC (ADC-135LCT)
      • Target: HER2
      • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
      Go to compare Compare
    • Anti-HER2 (trastuzumab)-auristatin ADC (ADC-138LCT)
      • Target: HER2
      • Linker: The linker contains two ethylene glycol moieties modified with a terminal alkoxy-amine group to improve solubility and minimize export of the more hydrophilic derivatized analogs by drug pumps
      • Drug: auristatin
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    • Anti-Her2-vc-[14C]MMAE ADC (ADC-221LZY)
      • Target: Her2
      • Linker: VC(valine-citrulline)
      • Drug: [14C]MMAE(14C-labeled monomethyl auristatin E)
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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.
    ERBB2 & CD3
    The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
    Related Diseases
    Bladder Cancer Bladder Cancer
    Non-small Cell Lung Cancer Non-small Cell Lung Cancer
    Related Signaling Pathways
    ErbB Signaling Pathway ErbB Signaling Pathway
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