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    ERBB2 & CD3

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    Anti-ERBB2 & CD3 Products

    • Anti-HER2-MT-vc-MMAE ADC (ADC-257CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-253CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-DBCO-MMAF ADC (ADC-310CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-254CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-DBCO-MMAF ADC (ADC-311CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-MP(T-vc)-MMAE ADC (ADC-255CL)
      • Target: HER2
      • Linker: MP(T-VC)
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino) phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-MC-vc-PABC-MMAE ADC (ADC-256CL)
      • Target: HER2
      • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: (S,E)-N-(4-(aminomethyl)benzylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-SMCC-DM1 ADC (ADC-001LZY)
      • Target: HER2
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-Her2-MCC-DM1 ADC (ADC-174LZY)
      • Target: Her2
      • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-Her2-mc-vc-PABC-MMAE ADC (ADC-175LZY)
      • Target: Her2
      • Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
      • Drug: MMAE (monomethyl auristatin E)
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    • Anti-HER2 (trastuzumab)-mcc-DM1 ADC (ADC-129LCT)
      • Target: HER2
      • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-258CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-SPP-DM1 ADC (ADC-132LZY)
      • Target: HER2
      • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-HER2-DUBA-Duocarmycins ADC (ADC-069LZY)
      • Target: HER2
      • Linker: DUBA (DUocarmycinhydroxyBenzamide-Azaindole
        linker) ("mc"-VC-PABC-CM)
      • Drug: Duocarmycins
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    • Anti-HER2-DBCO-MMAF ADC (ADC-307CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-[14C]-SMCC-DM1 ADC (ADC-150LZY)
      • Target: HER2
      • Linker: [14C]-SMCC
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-HER2-vc-MMAE ADC (ADC-081LZY)
      • Target: HER2
      • Linker: VC (valine-citrulline)
      • Drug: MMAE(monomethyl auristatin E)
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    • Anti-HER2-DBCO-MMAF ADC (ADC-309CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-DOX ADC (ADC-131LZY)
      • Target: HER2
      • Linker: thiomaleamicacids-p-aminobenzyloxycarbonyl
      • Drug: doxorubicin
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    • Anti-HER2-DBCO-MMAF ADC (ADC-308CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2 (trastuzumab)-SPDP-DM1 ADC (ADC-134LCT)
      • Target: HER2
      • Linker: SPDP ( N-succinimidyl 3-(2-pyridyldithio)propionate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
      Go to compare Compare
    • Anti-HER2 (trastuzumab)-SPP-DM1 ADC (ADC-135LCT)
      • Target: HER2
      • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-HER2 (trastuzumab)-auristatin ADC (ADC-138LCT)
      • Target: HER2
      • Linker: The linker contains two ethylene glycol moieties modified with a terminal alkoxy-amine group to improve solubility and minimize export of the more hydrophilic derivatized analogs by drug pumps
      • Drug: auristatin
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    • Anti-HER2-Gly5-modified DM1 ADC (ADC-147CL)
      • Target: HER2
      • Drug: Gly5-modified DM1 (Gly5-modified N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-Her2-VCP-cyclooctyne-MMAF ADC (ADC-210CL)
      • Target: Her2
      • Linker: valine-citruline-p-amino-benzoyl-carbonate (VCP)-cyclooctyne
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-vcPAB-MMAE ADC (ADC-148CL)
      • Target: HER2
      • Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: MMAE (Monomethyl auristatin E)
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-248CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
      Go to compare Compare
    • Anti-HER2-DBCO-MMAF ADC (ADC-295CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
      Go to compare Compare
    • Anti-HER2-MT-vc-MMAE ADC (ADC-249CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
      Go to compare Compare
    • Anti-HER2-DBCO-MMAF ADC (ADC-296CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
      Go to compare Compare
    • Anti-HER2-MT-vc-MMAE ADC (ADC-250CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
      Go to compare Compare
    • Anti-HER2-DBCO-MMAF ADC (ADC-297CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
      Go to compare Compare
    • Anti-HER2-MT-vc-MMAE ADC (ADC-251CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
      Go to compare Compare
    • Anti-HER2-DBCO-MMAF ADC (ADC-298CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
      Go to compare Compare
    • Anti-HER2-DBCO-MMAF ADC (ADC-299CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
      Go to compare Compare
    • Anti-HER2-MT-vc-MMAE ADC (ADC-252CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
      Go to compare Compare
    • Anti-HER2-BMPEO-DM1 ADC (ADC-186CL)
      • Target: HER2
      • Linker: BMPEO (bis-maleimido-trioxyethylene glycol)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
      Go to compare Compare
    • Anti-HER2-DBM-MMAF ADC (ADC-105LZY)
      • Target: HER2
      • Linker: DBM(dibromomaleimide)
      • Drug: MMAF(monomethyl auristatin F)
      Go to compare Compare
    • Anti-Her2-vc-[14C]MMAE ADC (ADC-221LZY)
      • Target: Her2
      • Linker: VC(valine-citrulline)
      • Drug: [14C]MMAE(14C-labeled monomethyl auristatin E)
      Go to compare Compare
    • Anti-HER2-mc-MMAF ADC (ADC-107LZY)
      • Target: HER2
      • Linker: mc(maleimidocaproyl)
      • Drug: MMAF(monomethyl auristatin F)
      Go to compare Compare
    • Anti-HER2-NGMs-MMAE ADC (ADC-035LZY)
      • Target: HER2
      • Linker: NGMs(next generation maleimides)
      • Drug: MMAE (monomethyl auristatin E)
      Go to compare Compare
    • Anti-HER2-DBCO-MMAF ADC (ADC-300CL)
      • Target: HER2
      • Linker: DBCO (Dibenzocyclooctyl)
      • Drug: MMAF (Monomethyl auristatin F)
      Go to compare Compare
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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
    ERBB2 & CD3
    CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.
    Related Diseases
    Bladder Cancer Bladder Cancer
    Non-small Cell Lung Cancer Non-small Cell Lung Cancer
    Related Signaling Pathways
    ErbB Signaling Pathway ErbB Signaling Pathway
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