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    ERBB2 & CD3

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    Anti-ERBB2 & CD3 Products

    • Anti-HER2 (trastuzumab)-auristatin ADC (ADC-138LCT)
      • Target: HER2
      • Linker: The linker contains two ethylene glycol moieties modified with a terminal alkoxy-amine group to improve solubility and minimize export of the more hydrophilic derivatized analogs by drug pumps
      • Drug: auristatin
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    • Anti-HER2-SMCC-DM1 ADC (ADC-001LZY)
      • Target: HER2
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-HER2 (trastuzumab)-mcc-DM1 ADC (ADC-129LCT)
      • Target: HER2
      • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-251CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-252CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-253CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-254CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-MP(T-vc)-MMAE ADC (ADC-255CL)
      • Target: HER2
      • Linker: MP(T-VC)
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino) phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-MC-vc-PABC-MMAE ADC (ADC-256CL)
      • Target: HER2
      • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: (S,E)-N-(4-(aminomethyl)benzylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-257CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-258CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-Her2-VCP-cyclooctyne-MMAF ADC (ADC-210CL)
      • Target: Her2
      • Linker: valine-citruline-p-amino-benzoyl-carbonate (VCP)-cyclooctyne
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-248CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-249CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2-MT-vc-MMAE ADC (ADC-250CL)
      • Target: HER2
      • Linker: MT-VC
      • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
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    • Anti-HER2 (trastuzumab)-SPDP-DM1 ADC (ADC-134LCT)
      • Target: HER2
      • Linker: SPDP ( N-succinimidyl 3-(2-pyridyldithio)propionate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-HER2 (trastuzumab)-SPP-DM1 ADC (ADC-135LCT)
      • Target: HER2
      • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-HER2-NGMs-MMAE ADC (ADC-035LZY)
      • Target: HER2
      • Linker: NGMs(next generation maleimides)
      • Drug: MMAE (monomethyl auristatin E)
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    • Anti-HER2-DBM-MMAF ADC (ADC-105LZY)
      • Target: HER2
      • Linker: DBM(dibromomaleimide)
      • Drug: MMAF(monomethyl auristatin F)
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    • Anti-HER2-mc-MMAF ADC (ADC-107LZY)
      • Target: HER2
      • Linker: mc(maleimidocaproyl)
      • Drug: MMAF(monomethyl auristatin F)
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    • Anti-HER2-DUBA-Duocarmycins ADC (ADC-069LZY)
      • Target: HER2
      • Linker: DUBA (DUocarmycinhydroxyBenzamide-Azaindole
        linker) ("mc"-VC-PABC-CM)
      • Drug: Duocarmycins
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    • Anti-HER2-DOX ADC (ADC-131LZY)
      • Target: HER2
      • Linker: thiomaleamicacids-p-aminobenzyloxycarbonyl
      • Drug: doxorubicin
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    • Anti-HER2-vc-MMAE ADC (ADC-081LZY)
      • Target: HER2
      • Linker: VC (valine-citrulline)
      • Drug: MMAE(monomethyl auristatin E)
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    • Anti-HER2-SPP-DM1 ADC (ADC-132LZY)
      • Target: HER2
      • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
      Go to compare Compare
    • Anti-HER2-[14C]-SMCC-DM1 ADC (ADC-150LZY)
      • Target: HER2
      • Linker: [14C]-SMCC
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-Her2-MCC-DM1 ADC (ADC-174LZY)
      • Target: Her2
      • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
      Go to compare Compare
    • Anti-Her2-mc-vc-PABC-MMAE ADC (ADC-175LZY)
      • Target: Her2
      • Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
      • Drug: MMAE (monomethyl auristatin E)
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    • Anti-HER2-Gly5-modified DM1 ADC (ADC-147CL)
      • Target: HER2
      • Drug: Gly5-modified DM1 (Gly5-modified N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-HER2-vcPAB-MMAE ADC (ADC-148CL)
      • Target: HER2
      • Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: MMAE (Monomethyl auristatin E)
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    • Anti-HER2-BMPEO-DM1 ADC (ADC-186CL)
      • Target: HER2
      • Linker: BMPEO (bis-maleimido-trioxyethylene glycol)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-Her2-vc-[14C]MMAE ADC (ADC-221LZY)
      • Target: Her2
      • Linker: VC(valine-citrulline)
      • Drug: [14C]MMAE(14C-labeled monomethyl auristatin E)
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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
    ERBB2 & CD3
    CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.
    Related Diseases
    Bladder Cancer Bladder Cancer
    Non-small Cell Lung Cancer Non-small Cell Lung Cancer
    Related Signaling Pathways
    ErbB Signaling Pathway ErbB Signaling Pathway
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