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ERBB2

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Anti-ERBB2 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


ERBB2, also known as HER2, encodes a receptor tyrosine kinase that is part of the epidermal growth factor receptor (EGFR) family. It is involved in cell growth, differentiation, and survival. ERBB2 overexpression is commonly found in certain types of cancer, particularly breast cancer, where it is associated with a more aggressive tumor phenotype. Targeted therapies such as trastuzumab (Herceptin) are used to treat HER2-positive breast cancer. ERBB2 also plays roles in other cancers and is a key player in signal transduction pathways that regulate cell proliferation and apoptosis.
ERBB2
Protein class

Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Collecting duct cells, Proximal enterocytes, Distal enterocytes)

Immune cell specificity

Immune cell enhanced (gdT-cell)

Cell line specificity

Group enriched (OE19, SK-BR-3)

Interaction

Homodimer (PubMed:21454582). Heterodimer with EGFR, ERBB3 and ERBB4 (PubMed:10358079, PubMed:15093539, PubMed:21190959, PubMed:16978839). Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196 (PubMed:10805725). Interacts with PLXNB1 (PubMed:15210733). Interacts (when phosphorylated on Tyr-1248) with MEMO1 (PubMed:15156151). Interacts with MUC1; the interaction is enhanced by heregulin (HRG) (PubMed:12939402). Interacts (when phosphorylated on Tyr-1139) with GRB7 (via SH2 domain) (PubMed:12975581). Interacts (when phosphorylated on Tyr-1248) with ERBIN (PubMed:12444095). Interacts with KPNB1, RANBP2, EEA1, CRM1 and CLTC (PubMed:16314522). Interacts with PTK6 (PubMed:18719096). Interacts with RPA194 and ACTB (PubMed:21555369). Interacts with PRKCABP, SRC and MYOC (By similarity). Interacts (preferentially with the tyrosine phosphorylated form) with CPNE3; this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner (PubMed:20010870). Interacts with HSP90AA1 and HSP90AB1 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity (PubMed:26517842). Interacts with SORL1; this interaction regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulates ERBB2-mediated signaling (PubMed:31138794).

Molecular function

Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase

More Types Infomation
Related Diseases
Bladder Cancer Bladder Cancer
Non-small Cell Lung Cancer Non-small Cell Lung Cancer
Related Signaling Pathways
ErbB Signaling Pathway ErbB Signaling Pathway
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