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ERBB2

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
  • Anti-HER2-MT-vc-MMAE ADC (ADC-258CL)

    • Target: HER2
    • Linker: MT-VC
    • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
  • Anti-HER2 (clone cFRP5)-SPP-DM1 ADC (ADC-066LZY)

    • Target: HER2
    • Linker: SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  • Anti-HER2-DOX ADC (ADC-131LZY)

    • Target: HER2
    • Linker: thiomaleamicacids-p-aminobenzyloxycarbonyl
    • Drug: doxorubicin
  • Anti-HER2-MT-vc-MMAE ADC (ADC-257CL)

    • Target: HER2
    • Linker: MT-VC
    • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
  • Anti-HER2-SMCC-maytansine ADC (ADC-065LZY)

    • Target: HER2
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: maytansine
  • Anti-HER2-MC-vc-PABC-MMAE ADC (ADC-256CL)

    • Target: HER2
    • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: (S,E)-N-(4-(aminomethyl)benzylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
  • Anti-HER2-NGMs-MMAE ADC (ADC-035LZY)

    • Target: HER2
    • Linker: NGMs(next generation maleimides)
    • Drug: MMAE (monomethyl auristatin E)
  • Anti-HER2-MP(T-vc)-MMAE ADC (ADC-255CL)

    • Target: HER2
    • Linker: MP(T-VC)
    • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino) phenylbutanamido)butanamido)hex-2-enamide
  • Anti-HER2-SMCC-DM1 ADC (ADC-001LZY)

    • Target: HER2
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  • Anti-HER2-MT-vc-MMAE ADC (ADC-254CL)

    • Target: HER2
    • Linker: MT-VC
    • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
  • Anti-HER2-MT-vc-MMAE ADC (ADC-253CL)

    • Target: HER2
    • Linker: MT-VC
    • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
  • Anti-HER2-MT-vc-MMAE ADC (ADC-252CL)

    • Target: HER2
    • Linker: MT-VC
    • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
  • Anti-HER2-BMPEO-DM1 ADC (ADC-186CL)

    • Target: HER2
    • Linker: BMPEO (bis-maleimido-trioxyethylene glycol)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
  • Anti-HER2-MT-vc-MMAE ADC (ADC-251CL)

    • Target: HER2
    • Linker: MT-VC
    • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
  • Anti-HER2-MT-vc-MMAE ADC (ADC-248CL)

    • Target: HER2
    • Linker: MT-VC
    • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
  • Anti-HER2-vcPAB-MMAE ADC (ADC-148CL)

    • Target: HER2
    • Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MMAE (Monomethyl auristatin E)
  • Anti-HER2-MT-vc-MMAE ADC (ADC-250CL)

    • Target: HER2
    • Linker: MT-VC
    • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide
  • Anti-HER2-MT-vc-MMAE ADC (ADC-249CL)

    • Target: HER2
    • Linker: MT-VC
    • Drug: (S,E)-N-(4-aminophenylsulfonyl)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enamide

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