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ERBB3

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This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Derivation:
Human
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Species Reactivity:
Cross-react with mouse ErbB3
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse ErbB4
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse ErbB5
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse ErbB6
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse ErbB7
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse ErbB8
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse ErbB9
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse ErbB10
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse ErbB11
Type:
Human antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
IF, ELISA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, WB, IP, FuncS
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Derivation:
Human
Species Reactivity:
Human
Type:
Antibody
Scaffold Name:
Z-domain of protein A
Target:
HER3
Species Reactivity:
Human
Derivation:
Phage display
Derivation:
Human
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, IF, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, BL, FuncS
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
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