Intracellular
Cell type enhanced (Extravillous trophoblasts, Plasma cells, Spermatogonia, Spermatocytes, Early spermatids, Erythroid cells)
Not detected in immune cells
Low cell line specificity
Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'->3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'->5' exonuclease activity and suppress the 5'->3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'->3' exonuclease activity and cleavage of 5'-overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures.
DNA-binding, Endonuclease, Excision nuclease, Exonuclease, Hydrolase, Nuclease
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For Research Use Only. Not For Clinical Use.